Duodenal bicarbonate secretion: eradication of Helicobacter pylori and duodenal structure and function in humans

Gastroenterology
D L HoganJon I Isenberg

Abstract

Eradication of Helicobacter pylori expedites duodenal ulcer healing and prevents recurrences. Most patients with duodenal ulcers have impaired proximal duodenal mucosal bicarbonate secretion (DMBS). In patients with inactive, healed duodenal ulcers and normal subjects, the effect of H. pylori infection on DMBS and proximal duodenal secretory function and structure were examined. DMBS was quantitated before and after eradication of H. pylori. Mucosal structure (duodenal bulb histopathology) and function (DMBS at rest and stimulated, effect of active vs. healed ulcer and of age) were determined in patients with duodenal ulcers and normal subjects. In patients with duodenal ulcers, H. pylori eradication normalized proximal DMBS. Histological examination of duodenal biopsy samples was comparable in patients with duodenal ulcers and normal subjects without apparent relationship between inflammation and DMBS. Significantly impaired DMBS occurred in response to all agonists tested (luminal acid, prostaglandin E2, and cephalic-vagal stimulation) in patients with duodenal ulcers, suggesting a generalized secretory defect. Neither the presence of active (vs.inactive) ulcer nor age significantly affected bicarbonate secretion. In patients...Continue Reading

Citations

Feb 3, 1999·Annals of the New York Academy of Sciences·M M Walker, J E Crabtree
Dec 19, 2001·The Journal of Clinical Investigation·Y AkibaJ D Kaunitz
Jul 1, 1997·Scandinavian Journal of Gastroenterology·J P GisbertA García Plaza
Aug 4, 2005·Upsala Journal of Medical Sciences·Markus Sjöblom
Feb 1, 1997·The American Journal of Medicine·R M Peek, M J Blaser
Feb 19, 2008·Medical Hypotheses·Jack W Love
Mar 27, 2007·Best Practice & Research. Clinical Gastroenterology·Larry H Lai, Joseph J Y Sung
Sep 20, 2005·Acta Physiologica Scandinavica·R LarsenN Bindslev
Jan 30, 2004·Journal of Gastroenterology and Hepatology·Izumi TanakaKei Kashima
May 9, 2008·Acta Physiologica·M Berner Hansen, A-B Witte
Jan 11, 2007·Alimentary Pharmacology & Therapeutics·J D Kaunitz, Y Akiba
Feb 1, 2006·Basic & Clinical Pharmacology & Toxicology·Bodil Elisabeth EngelmannMark Berner Hansen
Dec 16, 1998·The Journal of Laboratory and Clinical Medicine·V S PrathaJ I Isenberg
Sep 1, 2004·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P C KonturekE G Hahn
Dec 14, 2005·Current Problems in Surgery·Bruce E StabileDavid L Weeks
Apr 5, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·L OlbeA M Svennerholm
Sep 16, 1998·Journal of Gastroenterology and Hepatology·R H Hunt, S K Lam
Feb 24, 2001·Gastroenterology Clinics of North America·H Cohen
May 1, 1996·Digestive Diseases and Sciences·S E Miederer, P Grübel
Sep 30, 2006·The Keio Journal of Medicine·Jonathan D Kaunitz, Yasutada Akiba
May 15, 2008·The American Journal of Gastroenterology·Jack W Love
May 11, 1999·The American Journal of Gastroenterology·T LemboE A Mayer
Apr 3, 2007·Indian Journal of Pediatrics·Jagadish C Das, Nibedita Paul
Aug 23, 2005·Digestive Diseases and Sciences·Guillaume SavoyeAndré Smout
Dec 14, 2004·American Journal of Physiology. Cell Physiology·Adrian Allen, Gunnar Flemström
Oct 13, 2006·Current Opinion in Gastroenterology·Najeeb Zoubi, Chris J Dickinson
Aug 13, 1999·The American Journal of Physiology·G FlemströmA Allen
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhaohui WangManoocher Soleimani
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·G Flemström, J I Isenberg
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·Y AkibaJ D Kaunitz
Jun 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·M RepishtiJ I Isenberg
Feb 24, 2001·Annals of the New York Academy of Sciences·U SeidlerM Gregor
Jul 19, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gunnar FlemströmKarl E O Akerman
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·B T CooperT H Iqbal
Oct 2, 2002·Lancet·Francis K L Chan, W K Leung
Jun 15, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Ian C Roberts-Thomson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.