Duodenal expression of Toll-like receptors and interleukins are increased in both children and adult celiac patients.

Digestive Diseases and Sciences
Noemí EiróF J Vizoso

Abstract

Toll-like receptors (TLRs) have achieved an extraordinary amount of interest in inflammatory diseases due to their role in the inflammatory activation. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive the inflammatory response and activate the adaptive immune system. The aim of this study was to investigate and compare the expression and clinical relevance of TLRs and interleukins in pediatric and adult celiac disease (CD), defined as intolerance to dietary proteins found in wheat, barley, and rye. The expression levels of TLR3, TLR4, and TLR7, interleukins, and different transcription factors were analyzed on duodenal biopsies from ten children and 31 adults with CD, and 21 duodenal controls biopsies without CD (ten children and 11 adults). The analyses were performed by immunohistochemistry and real-time PCR. There were no significant differences in the studied parameters between adults and children. TLR4 expression level was increased twofold in CD specimens compared to controls. CD patients with high levels of TLR4 also showed high levels of interleukins (IL1, IL6, IL8, and IL17) as well as transcription factors (IRAK4, MyD88, and NF-κB). TLR4 expres...Continue Reading

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Citations

Jul 6, 2013·Digestive Diseases and Sciences·Se Jin Park, Jae Il Shin
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Silvia PellegriniLorenzo Piemonti
Apr 4, 2015·Expert Review of Gastroenterology & Hepatology·Renée M Marchioni Beery, John W Birk
Jul 6, 2014·The American Journal of Gastroenterology·Yvelise BarriosVictor Matheu
Feb 19, 2014·Journal of the American College of Nutrition·Pasquale MansuetoAntonio Carroccio
May 20, 2018·BMC Gastroenterology·Mohammad Rostami-NejadMohammad Reza Zali
Aug 22, 2017·Frontiers in Microbiology·Aaron LernerTorsten Matthias

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