Duodenal gangliocytic paraganglioma presenting as an ampullary tumor

International Journal of Pancreatology : Official Journal of the International Association of Pancreatology
J D EvansJ P Neoptolemos

Abstract

We report a case of a duodenal gangliocytic paraganglioma that had an unusual clinical presentation and atypical immunohistochemical features. Duodenal gangliocytic paragangliomas are rare tumors of the gastrointestinal tract with approx 70 cases reported in the literature. The most common presentation is with gastrointestinal bleeding, whereas obstructive jaundice is very uncommon. Immunohistochemistry typically shows positive epithelial cell staining for somatostatin, pancreatic polypeptide, and other neuroendocrine markers. A 56-yr-old man presented with intermittent episodes of epigastric pain, vomiting, and obstructive jaundice. Upper gastrointestinal endoscopy revealed a pedunculated ampullary tumor that was subsequently confirmed by computed tomography. At operation, there was marked secondary obstructive chronic pancreatitis in the remaining pancreas necessitating a pylorus-preserving total pancreatectomy. Histology confirmed typical features of a duodenal gangliocytic paraganglioma, but immunohistochemistry demonstrated negative staining for somatostatin and other polypeptides, which is in contrast to most other reported cases. Two years after surgery, the patient remains alive and well on medical treatment with no evi...Continue Reading

References

Sep 1, 1977·The American Journal of Surgical Pathology·R J ReedJ C Harkin
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·M BarbareschiM Falleni
Jul 1, 1989·American Journal of Clinical Pathology·A P Burke, E B Helwig
Nov 1, 1986·American Journal of Clinical Pathology·B W ScheithauerJ A Carney
Feb 1, 1986·The American Journal of Surgical Pathology·T Perrone
Jul 1, 1966·The American Journal of Digestive Diseases·W M LukashO F Nielsen
Jan 1, 1962·Virchows Archiv Für Pathologische Anatomie Und Physiologie Und Für Klinische Medizin·H B TAYLOR, E B HELWIG

❮ Previous
Next ❯

Citations

Jul 10, 2004·Gastroentérologie Clinique Et Biologique·Laurent GhoutiJean-Robert Delpero
Jun 12, 2009·Journal of Hepato-biliary-pancreatic Surgery·C M MannP Taniere

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

World Journal of Surgical Oncology
Junsik KwonSun-Whe Kim
Zhonghua nan ke xue = National journal of andrology
Jing ChenYuan-Jie Niu
Histopathology
S van EedenH L Blaauwgeers
Canadian Journal of Surgery. Journal Canadien De Chirurgie
G P Konok, G Sanchez-Cassis
© 2021 Meta ULC. All rights reserved