Duodenal gangliocytic paraganglioma. Report of a case and review of the literature.

Virchows Archiv. A, Pathological Anatomy and Histopathology
M BarbareschiM Falleni

Abstract

A case of gangliocytic paraganglioma (GP) of the ampulla of Vater is reported and the literature reviewed, with special attention to immunohistochemical studies. The present case, which occurred in a 56-year-old woman, shows the typical histological admixture of epithelioid, ganglion and spindle cells. Immunohistochemistry reveals strong reactivity for synaptophysin, Leu-7, somatostatin, S-100 protein and vimentin. A few ganglion cells are reactive for neurofilaments. Chromogranin A, myelin basic protein, desmin and cytokeratin are absent. Immunohistochemical data from literature regarding the cytoskeletal composition of GPs are not unequivocal: cytokeratin and neurofilament positivity is reported by some authors and denied by others. More uniformity is reported concerning the peptides produced by GPs: somatostatin and pancreatic polypeptide are the most frequently found antigens, followed by serotonin. General neuroendocrine markers like neuron specific enolase and protein gene product 9.5 are always positive, whereas chromogranins are rarely found. S-100 protein is always positive in the spindle cell component. Our data are in keeping with those previously reported and add the diffuse positivity for the Leu-7 antigen and the ...Continue Reading

References

Sep 1, 1977·The American Journal of Surgical Pathology·R J ReedJ C Harkin
Nov 1, 1986·American Journal of Clinical Pathology·B W ScheithauerJ A Carney
Feb 1, 1986·The American Journal of Surgical Pathology·T Perrone
Sep 1, 1987·Human Pathology·J M Martin, R T Maung
Jul 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·W C SandoB M Rodgers
Jan 1, 1985·Acta Neuropathologica·E WilanderT Movin
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KawaguchiN Goseki
Jul 1, 1966·The American Journal of Digestive Diseases·W M LukashO F Nielsen
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger

❮ Previous
Next ❯

Citations

Sep 1, 2011·Surgical Pathology Clinics·Dora Lam-Himlin
Nov 3, 2010·Annals of Diagnostic Pathology·Corwyn RowsellRunjan Chetty
Dec 30, 2006·Seminars in Diagnostic Pathology·Nancy DowMarkku Miettinen
Jul 3, 2004·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·K HarriesJ McK Manson
Nov 22, 2011·Diagnostic Cytopathology·Simone M DustinEdward B Stelow
Oct 29, 2005·Best Practice & Research. Clinical Gastroenterology·K Martin HoffmannRobert T Jensen
Jan 7, 2015·Experimental and Molecular Pathology·Nicholas LauSamuel French
Apr 13, 2004·Scandinavian Journal of Gastroenterology·P BucherPh Morel
Aug 1, 1996·Pathology International·M FurihataS Ohnishi
Apr 7, 2007·Digestive Diseases and Sciences·Tomoko MoritaSaburo Onishi
Feb 22, 2007·Neuroendocrinology·Robert T JensenUNKNOWN European Neuroendocrine Tumor Society
Jan 21, 2012·Neuroendocrinology·Gianfranco Delle FaveUNKNOWN Barcelona Consensus Conference participants
Oct 19, 2002·Archives of Pathology & Laboratory Medicine·Peter A Girgis, William A Henthorne
Jun 10, 2005·Annals of Diagnostic Pathology·Jose Antonio PlazaWilliam L Marsh
Oct 1, 1996·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·J D EvansJ P Neoptolemos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.