Duodenal GIST: a single center experience.

International Journal of Colorectal Disease
Alexander BehamMichael B Ghadimi

Abstract

The duodenum as primary site for gastrointestinal stromal tumors (GISTs) is rare and mitotic rate, tumor size, type of mutation and number of chromosomal aberrations have prognostic implications. We analyzed the outcome of 13 patients with duodenal GISTs who underwent surgical tumor resection. Either segmental duodenectomy or pylorus-preserving duodenopancreatectomy was performed. The tumors were histopathologically examined and the risk of progression was assessed based on tumor size and mitotic count. Additionally, mutation analysis of the KIT and PDGFRA receptor tyrosine kinase genes and comparative genomic hybridization (CGH) were performed in all cases. Eight patients underwent segmental duodenectomy and five patients were treated with pylorus-preserving duodenopancreatectomy. None of the five GISTs with low or no risk for malignancy according to the Miettinen classification developed tumor progress. In contrast, five of eight cases (62.5%) with high-risk tumors revealed tumor progress, and four of these patients died (50%). The median overall survival for all patients was 66 months, and the median disease-free survival 41 months. The operative procedure and type of mutation did not correlate with long-term survival. CGH a...Continue Reading

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Citations

Apr 24, 2014·World Journal of Surgical Oncology·Valentina BeltrameCosimo Sperti
Aug 1, 2015·Gastrointestinal Endoscopy·Moon Kyung JooYoung-Tae Bak
Mar 15, 2015·International Journal of Surgery Case Reports·Ameet KumarApoorv Singh
Aug 16, 2016·Gastroenterología y hepatología·Antonio Palomeque JiménezJosé Antonio Jiménez Ríos
May 1, 2020·Clinical and Translational Gastroenterology·Haojie DuGuoqiang Xu
Oct 18, 2020·International Journal of Surgery Case Reports·Andreia J SantosCarlos Casimiro
Aug 31, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Hany M El-HaddadIslam A El-Sayes

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Methods Mentioned

BETA
surgical resection
PCR
duodenopancreatectomy

Software Mentioned

Statistica

Related Concepts

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Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

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