Duodenal infusion of fat, cholecystokinin secretion and satiety in the pig

Physiology & Behavior
P C GregoryD V Rayner

Abstract

The influence of the cholecystokinin (CCK) antagonist L-364,718 (0.1 mg/kg) on short-term control of food intake was studied in 6 pigs. Arterial injection of L-364,718 abolished the inhibition of intake to CCK octapeptide infusion (4 micrograms/kg/hr; from 42% p less than 0.001, to 97% of control intake), but did not alter control intake (99%). Injection of L-364,718 also abolished the inhibition of intake to duodenal infusion of emulsified fat (12 g/hr; from 76% p less than 0.001 to 105%) and of monoglyceride (24 g/hr; from 64% p less than 0.001 to 101%), but did not alter the inhibition to oleic acid (60 g/hr; 48% p less than 0.01 and 61% p less than 0.02), to glycerol (127 g/hr; 84% p less than 0.05 and 89%) or to glucose (144 g/hr; 78% p less than 0.02 and 69% p less than 0.001). These results suggest that monoglyceride-induced CCK secretion is mainly responsible for the satiety to duodenal fat in the pig, but that there is also a CCK-independent effect via the fatty acid. The results further indicate that intake of a normal barley-based diet (2% fat) is controlled via CCK-independent mechanisms.

References

Apr 1, 1989·Physiology & Behavior·P C GregoryD V Rayner
Jul 1, 1985·The Proceedings of the Nutrition Society·T R Houpt
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R S Chang, V J Lotti
Apr 1, 1984·Regulatory Peptides·G Shillabeer, J S Davison

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Citations

Nov 1, 1993·Physiology & Behavior·D V Rayner, S Miller
Jan 1, 1991·Progress in Neurobiology·A J Silver, J E Morley
Jan 8, 2000·Physiology & Behavior·E Baranyiová, R L Hullinger
Jan 1, 1994·Baillière's Clinical Endocrinology and Metabolism·K C Lloyd
Jan 1, 1991·Critical Reviews in Food Science and Nutrition·K L Roehrig
Mar 23, 1994·Annals of the New York Academy of Sciences·R J LieverseC B Lamers
Mar 23, 1994·Annals of the New York Academy of Sciences·T A Woltman, R D Reidelberger
May 10, 2013·Canadian Journal of Physiology and Pharmacology·W Andrew Webster, Michael J Beyak
Apr 1, 1989·Physiology & Behavior·P C GregoryD V Rayner
Mar 1, 1996·Obesity Research·J Mei, C Erlanson-Albertsson
May 14, 2016·Nutrition Research Reviews·Eugeni RouraDavid Val-Laillet
Apr 30, 2017·Journal of Animal Physiology and Animal Nutrition·H LuK M Ajuwon
Apr 27, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C FeinleM Fried
Sep 3, 2019·Animal : an International Journal of Animal Bioscience·B HumphreyR Faris
Jun 1, 1993·Nutrition Reviews·D Greenberg
Jan 30, 1999·The American Journal of Clinical Nutrition·I M ChapmanM Horowitz
Dec 22, 1999·The American Journal of Physiology·D MatzingerC Beglinger
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J P GutzwillerC Beglinger
Feb 10, 1999·The American Journal of Physiology·L TrigazisG H Anderson
Feb 10, 1999·The American Journal of Physiology·B Burton-FreemanB O Schneeman

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