PMID: 4904222Dec 1, 1969Paper

Duodenal inhibition of gastric secretion by osmotic agents in normal subjects and patients with duodenal ulcer

Gut
A S WardC W Windsor

Abstract

Gastric secretion in man is inhibited by the presence in the duodenum of hyperosmolar and hypoosmolar solutions. Both acid and pepsin outputs are affected. There is no change in hydrogen, sodium, or potassium ion concentration in the gastric juice. Pepsin concentration, however, is reduced by all inhibitory stimuli. Inhibition is thought to act directly upon parietal and chief cells, and a possible basis for this mechanism is discussed. The response is similar in control subjects and duodenal ulcer patients; there is in particular no evidence of impaired inhibition in the ulcer group. An anomalous feature is the relatively small inhibition of acid output after hypertonic saline in control subjects compared with the duodenal ulcer patients.

References

Jan 1, 1968·Scandinavian Journal of Gastroenterology·H G DesaiK N Jeejeebhoy
Sep 1, 1953·The Journal of Physiology·J E THOMPSON, J R VANE
Jan 1, 1958·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·W SIRCUS
Jun 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·S KONTUREK, M I GROSSMAN
Feb 28, 1962·Annals of the New York Academy of Sciences·R MENGUY
Oct 29, 1951·The Journal of Physiology·J N HUNTW R SPURRELL
Jun 10, 1936·The Journal of Physiology·W J Griffiths
Sep 20, 1938·The Journal of General Physiology·M L Anson

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Citations

Oct 30, 1998·European Journal of Clinical Investigation·W F LamC B Lamers
Jan 1, 1990·Nutrition Research Reviews·A G Low
Jul 1, 1977·The Journal of Surgical Research·A M EbeidJ E Fischer
Sep 1, 1971·The Australian and New Zealand Journal of Psychiatry·G Andrews

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