Duodenal intraepithelial and lamina propria T lymphocytes in human immunodeficiency virus-infected patients with and without diarrhoea

Scandinavian Journal of Gastroenterology
F SnijdersF J ten Kate

Abstract

Diarrhoea is an important problem in human immunodeficiency virus (HIV)-infected patients. Intestinal pathologic conditions may arise from changes in local immunocyte populations. The aims of our study were to establish the histologic features of the duodenal mucosa of HIV-infected patients and to determine a) the phenotype of small-intestinal-intraepithelial (IELs) and lamina propria (LPLs)-lymphocytes; b) their degree of activation and differentiation within the lamina propria; and c) their relation to the presence of diarrhoea. Distal duodenal biopsy specimens were obtained prospectively from 29 HIV-infected patients-11 patients with diarrhoea (group 1) and 18 patients without diarrhoea (group 2)- and from 42 patients who had neither any risk factor for HIV nor diarrhoea (group 3). Histopathologic and immunohistochemical studies were combined with flow cytometric analysis, after separation of the mucosal intraepithelial compartment from the lamina propria. The median number of IELs and the percentage of gamma delta IELs were both unchanged in HIV-infected patients as compared with controls. In HIV-infected patients LP CD4 cells were decreased, and LP CD8 cells increased. No significant difference was found in the expression ...Continue Reading

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Citations

Jul 13, 2000·Veterinary Immunology and Immunopathology·P RoccabiancaP F Moore
Dec 12, 2001·HIV Medicine·Y M Miao, B G Gazzard
Aug 28, 2001·AIDS Research and Human Retroviruses·L KullerM B Agy
Jan 10, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F R MachadoM I S Duarte
Jan 6, 2007·Histopathology·S R Owens, J K Greenson
Dec 5, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Y M MiaoB G Gazzard

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