Duodenal intraepithelial lymphocytes in inflammatory disorders of the esophagus and stomach

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Mohammad M YousefBarbara F Banner

Abstract

Duodenal cluster designation 3 positive (CD3+) intraepithelial T lymphocytes (IELs) are increased in gluten-sensitive enteropathy (GSE) and, because of the dispersed nature of the gut immune system, might also be increased in mucosa distant from the duodenum. Conversely, little is known about their frequency in the duodenum during inflammatory conditions of the stomach and esophagus. This study assessed whether CD3+ IELs are increased in duodenal biopsies in patients with esophagitis or gastritis relative to normal control subjects. Cases (n=46) with concurrent mucosal biopsies of the duodenum, stomach, and esophagus were divided into 4 groups: I, no inflammation in any site; II, active esophagitis only; III, chronic active gastritis only, with Helicobacter pylori bacteria; IV, chronic gastritis only, without H pylori bacteria. Immunostains against CD3 were performed by using standard techniques, the number of CD3+ cells/100 enterocytes in 3 well-oriented villi was recorded, and the results for the groups were compared statistically. The average number of CD3+ IELs/100 enterocytes for each group was I, 6.7; II, 11.8; III, 7.2; and IV, 9.1. The differences among the groups were not statistically significant. There was no correla...Continue Reading

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Citations

Oct 5, 2010·Gastrointestinal Endoscopy·Susana GonzalezPeter H R Green
Apr 19, 2007·American Journal of Clinical Pathology·Smiljana IstvanicBarbara F Banner
Aug 25, 2009·Advances in Anatomic Pathology·Susanne W CarmackRobert M Genta
Sep 15, 2020·Journal of Pediatric Gastroenterology and Nutrition·Janaki DevaraImad Absah
May 23, 2007·Archives of Pathology & Laboratory Medicine·Noam HarpazSubhash Kini

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