Duodenal low-grade inflammation and expression of tight junction proteins in functional dyspepsia

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Masato TakiHiroto Miwa

Abstract

Duodenal changes in functional dyspepsia (FD) might be related to the development of symptoms. However, relationships among low-grade inflammation, Helicobacter pylori infection, and protein expression by tight junctions (TJs) in the duodenum are unclear. We therefore aimed to determine whether duodenal inflammation and genes associated with TJ proteins are associated with FD. We evaluated inflammatory cell infiltration of the duodenum, H pylori infection, and genes associated with TJ proteins in duodenal biopsy specimens from 35 patients with FD according to the Rome III diagnostic questionnaire and from 31 asymptomatic controls without structural diseases. We immunohistochemically detected eosinophils and mast cells and counted them. The expression of claudins, occludin, and zonula occludens (ZO)-1 mRNA was evaluated using quantitative RT-PCR. Infection with H pylori was determined by measuring serum antibodies, rapid urease or urea breath tests, and endoscopic findings. Sex, age, and H pyloriinfection rates did not differ between patients with FD and controls. The numbers of eosinophils and mast cells were significantly increased in patients with FD compared with controls and were significantly correlated. Inflammatory cell ...Continue Reading

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Citations

Apr 24, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Simon Keely, Nicholas J Talley
Apr 3, 2020·Journal of Neurogastroenterology and Motility·Ju Yup LeeDong Ho Lee
May 12, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Cristina MartínezBeate Niesler
Aug 9, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Shingo TakashimaYasuhiro Fujiwara
Apr 16, 2020·Arquivos De Gastroenterologia·Carine LeiteGuilherme Becker Sander
Mar 5, 2020·Arquivos De Gastroenterologia·Carine LeiteGuilherme Becker Sander
Dec 11, 2020·The American Journal of Gastroenterology·Jan TackFlorencia Carbone
Jan 20, 2021·Clinical and Translational Gastroenterology·Nicholas J TalleyAnna Andreasson
Nov 12, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shaoqi DuanYi Dai

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