Duodenal pH in cystic fibrosis and its relationship to fat malabsorption

Digestive Diseases and Sciences
P J RobinsonP D Sly

Abstract

To investigate the relationship between duodenal pH levels and supplemental pancreatic enzyme function in cystic fibrosis, 18 children with this condition had pH recordings performed from the second and fourth part of the duodenum. Compared to age-matched controls, patients with cystic fibrosis had significantly longer periods below a pH of 4.0 in the postprandial period and significantly less time above pH 5.8. These values correspond to the pH levels at which lipase is irreversibly destroyed (pH 4.0) and enteric coating of enzyme supplements dissolves (pH 5.8). A significant relationship was found between the pH recordings from the fourth part of the duodenum and the degree of residual fat malabsorption while taking enteric-coated enzyme supplements. Four patients with an excessively acidic duodenum and residual fat malabsorption despite high-dose enzyme supplementation were treated with misoprostol (Searle), a known acid-reducing agent. There were significant improvements in both duodenal pH values and fat absorption. We conclude that there is a wide range of duodenal pH values found in patients with cystic fibrosis and that the efficiency with which enzyme supplements work is closely related to these pH levels. Administrati...Continue Reading

References

Jan 1, 1989·Archives of Disease in Childhood·P J RobinsonS B Chitravanshi
Sep 1, 1988·Archives of Disease in Childhood·P J RobinsonA L Smith
May 1, 1987·Digestive Diseases and Sciences·C A YoungbergJ B Dressman
Jan 1, 1984·Journal of Pediatric Gastroenterology and Nutrition·A M Weber, C C Roy
Jan 1, 1982·Journal of Pediatric Gastroenterology and Nutrition·K L CoxM E Ament

❮ Previous
Next ❯

Citations

Mar 3, 2011·International Journal of Clinical Pharmacy·Jonathan L Kaye
Feb 1, 1992·Clinical Radiology·H Herlinger
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M SinaasappelG Döring
Dec 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·P C Gregory
Jan 27, 1998·Journal of Pediatric Gastroenterology and Nutrition·J C StevensS K Chong
Sep 18, 1998·Journal of Pediatric Gastroenterology and Nutrition·M P Walters, J M Littlewood
Dec 1, 1994·Journal of Paediatrics and Child Health·J M TursiG L Barnes
Aug 1, 1995·Journal of Paediatrics and Child Health·J M TursiG L Barnes
Jul 1, 1997·Archives of Disease in Childhood·J LeeP Durie
May 24, 2008·Annual Review of Nutrition·Sheila M Innis, A George F Davidson
Feb 24, 2001·Pharmacotherapy·N M DaviesF Jamali
Jul 15, 2011·Clinical and Experimental Gastroenterology·Aaron FiekerMartine Armand
Aug 11, 2000·Paediatric Drugs·J M Littlewood, S P Wolfe
Jul 27, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fang Liu, Abdul W Basit
Jul 30, 2015·Pharmaceutical Research·Anil R MaharajNikoletta Fotaki
Jan 11, 2007·Alimentary Pharmacology & Therapeutics·J D Kaunitz, Y Akiba
Oct 4, 2014·Pflügers Archiv : European journal of physiology·Steven D BroadbentMichael A Gray
Apr 5, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M Wouthuyzen-BakkerH J Verkade
Jan 18, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Julia L Matel
Jul 5, 2018·The Journal of Pharmacy and Pharmacology·Mariana GuimarãesNikoletta Fotaki
Oct 30, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zachary M SellersVijaya S Pratha
Nov 17, 2005·Pediatric Pulmonology·James M LittlewoodSteven P Conway
Oct 3, 2006·The Journal of Biological Chemistry·Xuefeng SuHong-Long Ji
Dec 31, 1992·Annals of the New York Academy of Sciences·D MacLean
Nov 7, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nancy M WalkerLane L Clarke
Dec 22, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zachary M SellersHui Dong
Aug 26, 1998·Journal of the Royal Society of Medicine·P DurieL Ellis
May 12, 1998·The American Journal of Physiology·L L Clarke, M C Harline
Jul 4, 2012·Scandinavian Journal of Gastroenterology·Caroline HedsundKlaus Krogh
Jan 1, 1996·Nutrition Reviews·J Dowsett
Jan 29, 1999·Physiological Reviews·P M Quinton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.