Duodenal somatostatinoma. Anatomic/clinical study of 12 operated cases

Annales de chirurgie
A HamyM F Le Bodic

Abstract

Duodenal somatostatinomas (DS) are very rare neuro-endocrine tumours. The aim of this retrospective and multicentric study was to report the clinical and pathological characteristics of these neoplasms in a series of 12 patients and to compare them with the literature. From 1987 to 1998, 12 patients were operated for a DS. There were seven women and five men ranging in age from 23 to 72 years (mean age: 56.6 years). Four patients had an associated von Recklinghausen's disease, one of them with multiple endocrine neoplasia (MEN type IIa) and medullary carcinoma of the thyroíd. The surgical procedures were pancreaticoduodenectomy (n = 8), small bowel resection (n = 2), inferior gastrectomy (n = 1) and gastrojejunostomy with hepatic metastases biopsies (n = 1). The tumour was mainly located on the 2nd duodenum (n = 10), with a mean size of 2.7 cm (ranging from 0.4 to 6 cm) and with a pancreatic invasion in three patients. A metastatic disease was present at the time of diagnosis in eight patients. There were, according to Capella's classification, two patients in the groups I and II, and ten patients in group III (83%), respectively. There was one postoperative death after a pancreaticoduodenectomy. Three patients secondarily died...Continue Reading

Citations

Sep 29, 2011·Annals of the Royal College of Surgeons of England·J M L WilliamsonR C N Williamson
Jan 6, 2005·Endocrine Reviews·Stephen J Marx, William F Simonds
Jul 25, 2007·Journal of Gastroenterology and Hepatology·Gabriella NesiFrancesco Tonelli
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Jul 4, 2017·Hereditary Cancer in Clinical Practice·Sergio CarreraGuillermo Lopez-Vivanco
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Jun 3, 2004·The Journal of Surgical Research·John C Mansour, Herbert Chen
Feb 6, 2008·Molecular and Cellular Endocrinology·M VolanteM Papotti

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