Duodenogastric reflux causes growth stimulation of foregut mucosa potentiated by gastric acid blockade

Digestive Diseases and Sciences
G WetscherT E Adrian

Abstract

We investigated whether duodenogastric reflux (DGR) together with gastroesophageal reflux causes growth stimulation of the foregut mucosa and if additional gastric acid suppression enhances the effect of DGR. DGR was induced in rats using a split gastroenterostomy. A cardiomyotomy was performed across the gastroeophageal junction in order to enhance reflux into the esophagus. DGR rats were divided into six subgroups: DGR, DGR + truncal vagotomy, DGR + omeprazole, DGR + gastrin receptor blockade, DGR + omeprazole + gastrin receptor blockade, and DGR + gastrin. Two sham groups, one with and one without omeprazole treatment, served as controls. DGR significantly increased the weight and DNA content of the esophageal and gastric mucosa, which was further enhanced by vagotomy or omeprazole. Histology revealed foveolar hyperplasia in the stomach and esophageal mucosal hyperplasia in these groups. In addition, severe esophagitis was found in the DGR group receiving omeprazole. Omeprazole without DGR had no growth-stimulating effect on the foregut mucosa. DGR-induced growth stimulation was accompanied by hypergastrinemia. Increased growth in the stomach but not the esophagus was inhibited by gastrin receptor blockade. Gastrin administr...Continue Reading

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Citations

Sep 8, 2004·Langenbeck's Archives of Surgery·H WykypielK Glaser
Feb 2, 1999·American Journal of Surgery·G J WetscherP Klinger
Sep 13, 2001·Alimentary Pharmacology & Therapeutics·P NetzerW Inauen
Oct 13, 2010·Current Problems in Surgery·Matthew J SchuchertRodney J Landreneau
Sep 26, 2006·Best Practice & Research. Clinical Gastroenterology·Paul A Atherfold, Janusz A Jankowski
Sep 20, 2000·Scandinavian Journal of Gastroenterology·D K ManifoldW J Owen
Oct 11, 2008·The American Journal of Gastroenterology·Stephen E AttwoodJanusz A Jankowski
Aug 28, 2001·Gastroenterology·J FreedmanJ Lagergren

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