Duodenum as a immediate brake to gastric outflow: a videofluoroscopic and manometric assessment

Gastroenterology
S S RaoK Schulze-Delrieu

Abstract

Duodenal infusion of HCl or lipid delays gastric emptying. The aim of this study was to assess whether this delay was in part caused by mechanical activity of the duodenum. Synchronized videofluoroscopy and manometry was used in 8 volunteers (5 men and 3 women) to examine contractile and flow patterns during duodenal infusion of 0.9% NaCl, HCl, 5% NaCl, bile, and sodium oleate, each mixed with 20% (wt/vol) barium sulfate. Within 15-30 seconds of infusion, HCl and 5% NaCl induced frequent large-amplitude contractions greater tha those induced by 0.9% NaCl. Initially, there was rapid dispersion of HCl followed by prolonged, tonic occlusion of the duodenum. The duodenal diameter decreased compared with that observed during 0.9% NaCl or oleate infusion. In contrast, after infusion of oleate or bile, duodenal diameter increased and there were fewer, smaller-amplitude, nonpropagating contractions with prolonged retention of solutions. Barium (20%; wt/vol) did not influence the motility index of any solution. HCl and 5% NaCl may restrict gastric outflow by inducing tonic occlusion of the duodenum, whereas bile and lipid may delay clearance by decreasing duodenal tone and contractility. Thus, the duodenum may serve as an immediate brak...Continue Reading

Citations

Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bryan LaulichtEdith Mathiowitz
May 19, 2010·International Journal of Molecular Sciences·Massimo D'ArchivioRoberta Masella
Apr 29, 2009·World Journal of Gastroenterology : WJG·Nenad FilipovicMilos Kojic
Jan 17, 2009·Advanced Drug Delivery Reviews·Randall J Mrsny
Jun 16, 2010·Journal of Gastroenterology and Hepatology·Manabu IshiiKen Haruma
Apr 20, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D Ramkumar, K S Schulze
Aug 13, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S PellissierC Jarrousse
Dec 17, 2003·Journal of Gastroenterology and Hepatology·Full-Young ChangHan Chang Wu
Feb 21, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Schulze
Nov 21, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K S Schulze, E Clark
May 1, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R G LentleJ P Chambers
Nov 10, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y KetoT Yokoyama
Feb 5, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·R G Lentle, C de Loubens
Jan 29, 2002·The American Journal of Gastroenterology·Yu-Chung SuMichael Horowitz
Aug 12, 2008·Gastroenterology·Carolina MalageladaJuan-R Malagelada
Mar 5, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T HauskenM Samsom
Aug 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K Schulze-Delrieu, R J Herman
Jan 27, 2017·Annual Review of Food Science and Technology·Colin D KayAlan Crozier
Jun 4, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Palash KarAdam M Deane
Sep 10, 2014·Computer Methods and Programs in Biomedicine·Aleksandar M CvetkovicNebojsa D Zdravkovic
Apr 19, 2017·Clinical and Experimental Pharmacology & Physiology·Anthony Y LinGregory O'Grady
Oct 31, 2002·JPEN. Journal of Parenteral and Enteral Nutrition·Mark T DeMeo, Keith Bruninga
Jan 17, 2002·The Journal of Comparative Neurology·Hiroyuki KonomiGino T P Saccone
Dec 3, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B MearadjiA A Masclee
May 8, 1999·Alimentary Pharmacology & Therapeutics·M A VerhagenL M Akkermans
Jul 11, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M CastedalH Abrahamsson
May 10, 2008·European Journal of Gastroenterology & Hepatology·Martina Führer, Johann Hammer
May 7, 2004·The American Journal of Gastroenterology·Michio Hongo
Mar 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·John DentJohn William Arkwright
Dec 20, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·G SavoyeA J P M Smout
Jun 11, 1999·The American Journal of Physiology·K Schulze-Delrieu
Jul 19, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Céline Savoye-ColletAndré Smout
Sep 30, 2006·World Journal of Gastroenterology : WJG·Huan Nam NguyenFrank Lammert
Oct 3, 2019·IUCrJ·Weili ZhengEdward Egelman
Jan 31, 2002·World Journal of Gastroenterology : WJG·Yin-Ai WuShi-Xiong Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
M KogureT Nishioka
The American Journal of Physiology
V MartínezP Vergara
Revista de enfermería
I Sánchez Zaplana, M Zaragoza Arnau
© 2021 Meta ULC. All rights reserved