Duplicated major histocompatibility complex class II genes in the tongue sole (Cynoglossus semilaevis)

International Journal of Immunogenetics
C LiXubo Wang

Abstract

The major histocompatibility complex (MHC) molecule plays an important role in the vertebrate immune system. However, we have a limited understanding of the MHC genomic structure in teleosts. Using gene cloning and family analysis, we isolate the MHC class II genes in the tongue sole (Cynoglossus semilaevis) and find that both class II A and class II B genes are duplicated (named Cyse-DAA and Cyse-DBA, Cyse-DAB and Cyse-DBB, respectively). The class II A genes consist of four exons with a highly conserved genomic structure, but each gene has unique and defining exon 2 and intron 2 sequences. The class II B genes have a conserved six-exon genomic structure, with intron 3 splitting the β2 encoding region into two exons. Each class II B gene has unique variations in exon 2 and intron 1 sequences. The two class II A genes have similar expression patterns among tissues, with high levels in spleen and gill. Both class II B genes have similar patterns, with high expression in spleen, gill and intestine. The alleles of MHC class II have wide distribution and reliable inheritance in the families analysed. This indicates that the duplicated MHC genes are all classical class II genes. The class II gene duplication with divergent exon and ...Continue Reading

References

Feb 1, 1992·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J Trowsdale, R D Campbell
Mar 22, 1995·Proceedings. Biological Sciences·F FigueroaJ Klein
Jan 1, 1993·Annual Review of Immunology·J KleinN Takahata
Jan 1, 1997·Developmental and Comparative Immunology·U B GodwinT J McConnell
Mar 31, 1998·Scandinavian Journal of Immunology·J Klein, A Sato
Dec 24, 1998·Nucleic Acids Research·G Benson
May 13, 1999·Immunological Reviews·T F BergströmU Gyllensten
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y OhtaM F Flajnik
Jun 1, 2000·Developmental and Comparative Immunology·U B GodwinT J McConnell
Jun 1, 2000·The Journal of Heredity·K TakahashiM Nei
Sep 21, 2002·Immunogenetics·Jennifer G SambrookMelody S Clark
Feb 13, 2004·Marine Biotechnology·M NonakaA Shima
Feb 6, 2010·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yeying SunChunmei Li

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