Duplication and Nuclear Envelope Insertion of the Yeast Microtubule Organizing Centre, the Spindle Pole Body

Cells
Diana Rüthnick, Elmar Schiebel

Abstract

The main microtubule organizing centre in the unicellular model organisms Saccharomyces cerevisiae and Schizosaccharomyces pompe is the spindle pole body (SPB). The SPB is a multilayer structure, which duplicates exactly once per cell cycle. Unlike higher eukaryotic cells, both yeast model organisms undergo mitosis without breakdown of the nuclear envelope (NE), a so-called closed mitosis. Therefore, in order to simultaneously nucleate nuclear and cytoplasmic MTs, it is vital to embed the SPB into the NE at least during mitosis, similarly to the nuclear pore complex (NPC). This review aims to embrace the current knowledge of the SPB duplication cycle with special emphasis on the critical step of the insertion of the new SPB into the NE.

References

Jan 1, 1974·Cold Spring Harbor Symposia on Quantitative Biology·B Byers, L Goetsch
Aug 1, 1971·The Journal of Cell Biology·P B Moens, E Rapport
Apr 1, 1966·The Journal of Cell Biology·C F Robinow, J Marak
Apr 1, 1994·The Journal of Cell Biology·R W WozniakM P Rout
Apr 8, 1994·Science·Y ChikashigeY Hiraoka
Aug 1, 1993·The Journal of Cell Biology·M WineyB Byers
Apr 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ItoY Sakaki
Aug 15, 2002·Current Biology : CB·Jeffrey L SalisburyMargaret Springett
Sep 6, 2002·Oncogene·Pheruza Tarapore, Kenji Fukasawa
Mar 22, 2003·Journal of Structural Biology·Jenny E Hinshaw, Ronald A Milligan
Jul 15, 2003·Molecular Biology of the Cell·Anne PaolettiMichel Bornens
Jun 1, 1961·The Journal of Biophysical and Biochemical Cytology·J G GALL
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Sue L Jaspersen, Mark Winey
Apr 22, 2006·Science·Maximiliano A D'AngeloMartin W Hetzer
Jun 21, 2006·The Journal of Cell Biology·Sam LiJohn V Kilmartin
Nov 30, 2007·Nature·Frank AlberMichael P Rout
Apr 8, 2009·The Journal of Cell Biology·Juliette AzimzadehMichel Bornens
May 6, 2009·The Journal of Cell Biology·Evgeny OnischenkoKarsten Weis

❮ Previous
Next ❯

Citations

May 12, 2019·G3 : Genes - Genomes - Genetics·Rowan S M HowellPeter H Thorpe
Jun 3, 2020·Communications Biology·Yasuhiro HiranoYasushi Hiraoka
Jul 11, 2018·Cells·Daisuke Ito, Mónica Bettencourt-Dias
Feb 2, 2021·The Journal of Cell Biology·Diana RüthnickElmar Schiebel
Oct 29, 2020·Current Opinion in Structural Biology·Sue L Jaspersen
Jul 1, 2019·G3 : Genes - Genomes - Genetics·Rowan S M HowellPeter H Thorpe
Sep 19, 2021·Life Science Alliance·Caroline S SimonJulien Guizetti

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
electron tomography
super-resolution microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.