Duplication of phospholipase C-delta gene family in fish genomes

Genomics
Moo-Sang KimJoon Ki Chung

Abstract

Fishes possess more genes than other vertebrates, possibly because of a genome duplication event during the evolution of the teleost (ray-finned) fish lineage. To further explore this idea, we cloned five genes encoding phosphoinositide-specific phospholipase C-delta (PLC-delta), designated respectively PoPLC-deltas, from olive flounder (Paralichthys olivaceus), and we performed phylogenetic analysis and sequence comparison to compare our putative gene products (PoPLC-deltas) with the sequences of known human PLC isoforms. The deduced amino acid sequences shared high sequence identity with human PLC-delta1, -delta3, and -delta4 isozymes and exhibited similar primary structures. In phylogenetic analysis of PoPLC-deltas with PLC-deltas of five teleost fishes (zebrafish, stickleback, medaka, Tetraodon, and Takifugu), three tetrapods (human, chicken, and frog), and two tunicates (sea squirt and pacific sea squirt), whose putative sequences of PLC-delta are available in Ensembl genome browser, the result also indicated that the two paralogous genes corresponding to each PLC-delta isoform originated from fish-specific genome duplication prior to the divergence of teleost fish. Our analyses suggest that an ancestral PLC-delta gene und...Continue Reading

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Citations

May 1, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Na Young KimJoon Ki Chung
Sep 14, 2013·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Hye Jin BakJoon Ki Chung
Jan 25, 2011·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Carlos InfanteManuel Manchado

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