Durability of every-8-week aflibercept maintenance therapy in treatment-experienced neovascular age-related macular degeneration

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Kunny C DansWilliam R Freeman

Abstract

To determine the proportion of treatment-experienced eyes with exudative age-related macular degeneration successfully treated with every-4-week aflibercept that can be kept dry on fixed every-8-week aflibercept injections (maintenance). In this retrospective chart review, we evaluated our cohort of patients treated with a treatment paradigm for CNV in AMD. Initially, patients were treated with bevacizumab or ranibizumab and switched to every-4-week aflibercept when therapeutic responses were not durable or were suboptimal. Maintenance every-8-week therapy was initiated when the retina was completely dry on every-4-week aflibercept therapy. The primary outcome measure was recurrence of exudation on optical coherence tomography (OCT) during maintenance. Thirty-six eyes of 31 consecutive patients with median age of 79 years (range, 65-89) were included. Maintenance was started after a median of 34 (range, 8-88) injections. Recurrence was observed in 20 eyes (55%). Of these, 11 eyes (31%) reactivated at 8 weeks. Median time to failure of maintenance schedule was 40 weeks by Kaplan-Meier analysis. Baseline demographic and anatomic characteristics were not associated with failure of maintenance schedule. In treatment-experienced eye...Continue Reading

References

May 5, 2012·Ophthalmology·UNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research GroupFrederick L Ferris
Oct 23, 2012·Ophthalmology·Jeffrey S HeierUNKNOWN VIEW 1 and VIEW 2 Study Groups
May 21, 2014·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Kavita V Bhavsar, K Bailey Freund
Dec 3, 2014·American Journal of Ophthalmology·Cheryl A ArcinueWilliam R Freeman
Oct 20, 2015·Ophthalmology·Gisbert RichardOliver Zeitz
Jan 20, 2016·Ophthalmology·Sumit SharmaUNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials Research Group
Apr 7, 2016·American Journal of Ophthalmology·Ilkay Kilic MuftuogluWilliam R Freeman

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Citations

Aug 23, 2020·The British Journal of Ophthalmology·Melina CavichiniWilliam R Freeman

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