Durability of Roux-en-Y gastric bypass surgery: a meta-regression study

Annals of Surgery
Mark A AttiahSherman C Stein

Abstract

The present meta-regression pools data from reports of long-term follow-up (>2 years) to assess durability of the efficacy associated with Roux-en-Y gastric bypass (RYGB) surgery. Medline and PubMed searches for articles pertaining to long-term weight loss after RYGB surgery were performed. Various studies have consistently shown short-term (<2 years) efficacy of RYGB surgery for morbid obesity, corroborated by meta-analytic techniques. Relatively few studies have assessed efficacy over longer periods of time. This is the first meta-analysis to analyze long-term effects of RYGB surgery on weight loss. Twenty-two reports with a total of 4206 patient cases were included. Sixteen of the 22 studies had multiple follow-up times, ranging from 2 to 12.3 years (mean: 3.6 years). An inverse variance weighted model and meta-regression were used to generate the pooled percent mean excess weight loss (EWL) and the durability of EWL over time, respectively. Meta-regression did not reveal any significant change in EWL over time. Pooled mean EWL was 66.5%, and there was no significant association between EWL and length of follow-up. Pooling data from multiple studies meta-analytically revealed that weight loss after RYGB is maintained over th...Continue Reading

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Citations

Jan 24, 2015·The Indian Journal of Surgery·Abeezar I Sarela
Oct 18, 2015·Obesity Surgery·Carlos ZerrweckLizbeth Guilbert
Oct 27, 2015·Current Atherosclerosis Reports·Ted D AdamsSteven C Hunt
Jan 21, 2014·Annals of Surgery·Abdulzahra Hussain, Shamsi El-Hasani

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