Durable Complete Radiological Response to Nivolumab in Two Heavily Pretreated Western Elderly Patients With Metastatic Gastric Cancer: A Case Report

Frontiers in Oncology
Giuseppe TirinoFerdinando De Vita

Abstract

Background: The prognosis of patients with advanced gastric cancer remains overall poor despite some recent innovations and the development of new therapeutic approaches. Current European guidelines do not recommend any specific treatment for patients with advanced gastric cancer refractory to two or more previous chemotherapy regimens, making this setting "orphan." Immunotherapy is quickly evolving also for this malignancy even if with controversial results and the correct patient selection is still debated, especially for Western patients. The phase III ONO-4538-12 "ATTRACTION-2" represents the current landmark trial for the development of immunotherapy for pretreated Asian patients and led to the approval of Nivolumab in some Asian countries, while only previous phase trials are available for Caucasians. Complete radiological response is anecdotic and has never been described both in the pivotal trial both in the others with Western patients enrolled. Case presentation: We report two cases of heavily pretreated Western elderly patients with metastatic gastric cancer who experienced durable complete radiological response to Nivolumab "off label" (more than 20 months to date) in a clinical practice context. Molecular analysis ...Continue Reading

References

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May 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lawrence H SchwartzLesley Seymour
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Feb 1, 2017·Translational Gastroenterology and Hepatology·Daniele MarrelliFranco Roviello
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Aug 16, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Yelena Y JanjigianDung T Le
Sep 13, 2018·International Journal of Molecular Sciences·Giuseppe TirinoFerdinando De Vita
Feb 2, 2019·Journal for Immunotherapy of Cancer·Saori MishimaKohei Shitara
Feb 23, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Leigh MarcusRichard Pazdur
Mar 27, 2019·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yung-Jue BangHyun Cheol Chung

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