Durable response to combination radiotherapy and immunotherapy in EP-resistant lung large-cell neuroendocrine carcinoma with B2M and STK11 mutations: a case report

Immunotherapy
Yi QinMeijuan Huang

Abstract

Lung large-cell neuroendocrine carcinoma (LCNEC) is a rare tumor with poor prognosis. Despite the increasing prevalence of immune checkpoint inhibitors (ICIs) across a broad spectrum of solid tumors, very limited information is available about the efficacy in LCNEC. Here, we report a case of advanced lung LCNEC treated with combined radiotherapy and ICIs, which resulted in a durable response. We also focused on the impressive reaction of metastatic and primary lesions to two different combination modes of radiotherapy and ICIs.

References

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Citations

Feb 13, 2021·Diagnostics·Baharia MograbiPaul Hofman
Feb 19, 2021·Journal for Immunotherapy of Cancer·Elizabeth DudnikUNKNOWN Israel Lung Cancer Group

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Methods Mentioned

BETA
biopsy
biopsies

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