Dural Invasion Predicts the Laterality and Development of Neck Metastases in Esthesioneuroblastoma

Journal of Neurological Surgery. Part B, Skull Base
John P MarinelliDaniel L Price

Abstract

Objectives  Neck metastases in patients with esthesioneuroblastoma (ENB) constitute the most significant predictor of poor long-term survival. Recently, researchers discovered the existence of dural lymphatic channels that drain to the cervical lymph nodes. From this physiologic basis, we hypothesized that patients with ENB who develop dural invasion (DI) would exhibit a proclivity for neck metastases. Design  Retrospective review. Setting  Tertiary referral center. Participants  All patients treated for ENB from January 1, 1994 to December 31, 2015. Main Outcome Measures  Incidence, laterality, and recurrence rate of neck metastases by DI status. Results  Sixty-one patients were identified (38% female; median age 49, range, 10-80), 34 (56%) of whom had DI and 27 (44%) did not. Of patients with DI, 50% presented with or developed neck disease following treatment compared with just 22% of those without DI ( p  = 0.026). Bilateral neck disease was more common in patients with DI (11/34, 32%) compared with those without (2/27, 7%) ( p  = 0.018). Five-year regional recurrence-free survival rates were 88% for those without and 64% for those with DI ( p  = 0.022). Kadish C patients with DI were more likely to develop regional recurre...Continue Reading

Citations

Jul 27, 2021·Journal of Neurological Surgery. Part B, Skull Base·Kevin C MillerJamie J Van Gompel

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