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Dural lymphatics regulate clearance of extracellular tau from the CNS

Molecular Neurodegeneration

Feb 27, 2019

Tirth K PatelDavid. M. Holtzman

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Abstract

Alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms insoluble, hyperphosphorylate...read more

Mentioned in this Paper

Extracellular Space
Plasma
Study
Cell Body of Neuron
Wild Type Mouse
X-Ray Computed Tomography
MAPT protein, human
Tauopathies
Extracellular
Brain
31
1
2
61

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Dural lymphatics regulate clearance of extracellular tau from the CNS

Molecular Neurodegeneration

Feb 27, 2019

Tirth K PatelDavid. M. Holtzman

PMID: 30813965

DOI: 10.1186/s13024-019-0312-x

Abstract

Alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms insoluble, hyperphosphorylate...read more

Mentioned in this Paper

Extracellular Space
Plasma
Study
Cell Body of Neuron
Wild Type Mouse
31
1
2
61

Similar Papers Found In These Feeds

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