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Dural lymphatics regulate clearance of extracellular tau from the CNS

Molecular Neurodegeneration

Mar 1, 2019

Tirth K PatelDavid M Holtzman

Abstract

Alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms insoluble, hyperphosphorylate...read more

Mentioned in this Paper

Study
Tauopathies
Parenchyma
MIR100HG
Extracellular
Extracellular Space
Brain
ALB
Albumin Human, USP
Molecular_function
32
1
2
71
Paper Details
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Dural lymphatics regulate clearance of extracellular tau from the CNS

Molecular Neurodegeneration

Mar 1, 2019

Tirth K PatelDavid M Holtzman

PMID: 30813965

DOI: 10.1186/s13024-019-0312-x

Abstract

Alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of tau protein. Although tau is normally a soluble monomer that bind microtubules, in disease it forms insoluble, hyperphosphorylate...read more

Mentioned in this Paper

Study
Tauopathies
Parenchyma
MIR100HG
Extracellular
Extracellular Space
Brain
ALB
Albumin Human, USP
Molecular_function
32
1
2
71

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ALS & FTD: TDP-43

ALS shares with a considerable proportion of FTD cases the same neuropathological substrate, namely, inclusions of abnormally phosphorylated protein tdp-43 (ptdp-43). Here are the latest discoveries pertaining to ptdp-43 and these diseases.

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Proceedings of the National Academy of Sciences of the United States of America

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Paper Details
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