Duration and Dosage of Opioids After Spine Surgery: Implications on Outcomes at 1 Year.

Spine
Jeffrey M HillsJacquelyn S Pennings

Abstract

Longitudinal Cohort Study OBJECTIVE.: The aim of this study was to determine whether duration of postoperative opioids is associated with long-term outcomes, and if initial postoperative opioid dosage is associated with opioid cessation after spine surgery. Preoperative opioid use is associated with poor outcomes, but little evidence exists regarding the implications of opioid dosage and duration after spine surgery. Data from our state's prescription drug database was linked to our prospective clinical spine registry to analyze opioid dispensing and outcomes in elective surgical spine patients between 2010 and 2017. Patients were stratified based on preoperative chronic opioid use and multivariable regression was used to assess associations between duration of postoperative opioids and outcomes at one year, including satisfaction, chronic opioid use, and meaningful improvements in pain, disability, and quality of life. In a secondary aim, a Cox proportional hazards model was used to determine whether initial postoperative opioid dosage was associated with time to opioid cessation. Of 2172 patients included, 35% had preoperative chronic opioid use. In patients without preoperative chronic opioid use, a postoperative opioid dura...Continue Reading

References

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May 13, 2019·The Spine Journal : Official Journal of the North American Spine Society·Aditya V KarhadeAndrew J Schoenfeld

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Citations

Jan 19, 2021·The Spine Journal : Official Journal of the North American Spine Society·Lara MassieJason M Schwalb
Apr 20, 2021·The Spine Journal : Official Journal of the North American Spine Society·Nikhil JainMaxwell Boakye

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