PMID: 8448295Jan 1, 1993Paper

Duration and efficacy of immune response to hepatitis B vaccine in high-risk Chinese adolescents

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Z MintaiR A Smego

Abstract

The long-term immunogenicity and protection provided by a plasma-derived hepatitis B vaccine was determined in a cohort of susceptible Chinese adolescents who were immunized in 1986. Ninety-five children, aged 13 to 15 years, received three vaccine doses (at 0, 1, and 2 months), and during subsequent annual follow-ups for 5 years, their serological markers for hepatitis B virus and levels of alanine aminotransferase were determined. After the primary vaccine series, 94 subjects (99%) developed antibody to hepatitis B surface antigen (anti-HBs). At the 60-month follow-up, 73% of vaccinees still had levels of antibody at or above 10 mIU/mL, which is considered the protective level. Nine vaccine responders (9%) developed antibody to hepatitis B core antigen, and in eight of these individuals, levels of anti-HBs increased transiently. None of the adolescents developed detectable levels of hepatitis B surface antigen or clinical hepatitis. Immunization of high-risk adolescents with a plasma-derived hepatitis B vaccine can induce long-lasting protective immunity that can prevent or modify primary infection for at least 5 years. Immunization with booster doses is not necessary during this period.

Citations

Mar 1, 1997·The Journal of Infection·C GoilavA Zuckerman
Jun 9, 2016·The Cochrane Database of Systematic Reviews·Jalal Poorolajal, Elham Hooshmand
Jul 16, 2011·The Korean Journal of Hepatology·So Young Kwon, Chang Hong Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.