Duration but not intensity of alcohol and tobacco exposure predicts p16INK4A homozygous deletion in head and neck squamous cell carcinoma

Cancer Research
Kim S KraunzKarl T Kelsey

Abstract

In tobacco-associated solid tumors, evidence suggests that the pattern of carcinogen exposure is related to the nature of somatic gene inactivation within crucial pathways, including the retinoblastoma (Rb) pathway. One somatic event in this pathway, homozygous deletion of the p16INK4A gene, is commonly observed in head and neck squamous cell carcinoma (HNSCC). Alcohol and tobacco are both well-established risk factors for HNSCC but there has been little characterization of the relationship of exposure to these carcinogens and inactivation of the p16INK4A gene. Hypothesizing that p16INK4A homozygous deletion is associated with tobacco and alcohol exposure, we investigated 330 consecutive HNSCC tumors. The odds ratio (OR) for p16INK4A homozygous deletion among alcohol consumers in the upper tertile (>43 years used) was 5.2 [95% confidence interval (95% CI), 2.1-12.8] as compared with those with < or = 43 years of alcohol consumption. Intensity of alcohol exposure, measured as average alcoholic drinks per week, was not associated with gene deletion. When we examined the distribution of duration of tobacco use, the OR for p16(INK4A) homozygous deletion was 1.3 (95% CI, 0.5-3.0) and 1.9 (95% CI, 0.9-4.0) for 29 to 39 years and >39 ...Continue Reading

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Citations

Oct 17, 2015·Molecular Cancer·Maarouf A SaadWeg M Ongkeko
May 6, 2015·International Dental Journal·Bhawna GuptaNewell W Johnson
Jun 18, 2014·Journal of Medical Genetics·Hildur HelgadottirJohan Hansson
Apr 4, 2017·Scientific Reports·Paola NieriAdriano Podestà
May 22, 2008·Journal of Surgical Oncology·Bhuvanesh Singh
Oct 6, 2006·Expert Review of Anticancer Therapy·Ralph PriesBarbara Wollenberg

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