PMID: 18186225Jan 12, 2008Paper

Duration-dependent effects of the bite-raised condition on hippocampal function in SAMP8 mice

Okajimas Folia Anatomica Japonica
Yoko ArakawaKin-Ya Kubo

Abstract

We evaluated the effect of the duration of occlusal disharmony induced chronic stress on hippocampal function by examining spatial memory in the Morris water maze and on the number of hippocampal neurons in aged senescence-accelerated prone (SAMP8) mice. The bite of SAMP8 mice was raised 0.1 mm using dental adhesive. Groups of mice were tested in the Morris water maze 8, 11, or 22 d after raising the bite. The results indicated that the longer the duration of the bite-raised condition, the greater the impairment in spatial learning ability and the greater the decrease in the number of neurons in the hippocampal CA3 subfield. Thus, behavioral and morphologic deficits induced by the bite-raised condition in aged SAMP8 mice are influenced by the duration of the occlusal disharmony.

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·J F Flood, J E Morley
Jun 17, 1999·Journal of Dental Research·M P AresoF M Gómez

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Citations

Mar 2, 2012·BMC Neuroscience·Marina Negrão Frota de AlmeidaMarcia Consentino Kronka Sosthenes
Jun 29, 2013·BMC Neuroscience·Fabíola de Carvalho Chaves de Siqueira MendesMarcia Consentino Kronka Sosthenes
Dec 24, 2010·Okajimas Folia Anatomica Japonica·Kin-Ya KuboYasuo Tamura
Mar 20, 2010·Journal of Oral Rehabilitation·Y OnoM Onozuka

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