PMID: 6106456Jan 1, 1980Paper

Duration of action and plasma levels of beta-adrenoceptor blocking drugs

Archives Internationales De Pharmacodynamie Et De Thérapie
W H Aellig

Abstract

Since beta-adrenoceptor blocking drugs exhibit a long duration of action "despite" an elimination half-life of usually between 2 and 6 hours, it has been postulated that no direct correlation could exist between the time course of plasma levels and that of pharmacodynamic effects. Results of a study are reported in which 20 mg pindolol were administered orally to 8 healthy volunteers. Exercise tests were carried out and pindolol levels determined at various times for up to 24 hours after drug administration. A linear fall of the pharmacological effect (reduction of exercise-induced tachycardia) and an exponential fall of pindolol plasma levels were observed, indicating a linear relationship between the reduction of exercise-induced tachycardia and the logarithm of plasma concentration.

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.