Duration of adjuvant chemotherapy for colon cancer and survival among the elderly

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Alfred I NeugutDawn Hershman

Abstract

In randomized trials, patients with stage III colon cancer who received 6 months of fluorouracil (FU)-based adjuvant chemotherapy had better survival than patients who did not. However, little is known about the predictors of, or the survival associated with, duration of chemotherapy in the community. The linked Surveillance, Epidemiology, and End Results-Medicare database was used to identify individuals > or = 65 years of age diagnosed with stage III colon cancer between 1995 and 1999. We used logistic and Cox proportional hazards regression models to analyze factors associated with early discontinuation of FU-based chemotherapy among these elderly colon cancer patients. Among 1,722 patients who received 1 to 7 months of FU-based chemotherapy, older age, being unmarried, and having comorbid conditions were associated with receiving less than 5 months of treatment. Among the 1,579 patients who survived > or = 8 months, the 1,091 (69.1%) who received 5 to 7 months of treatment had lower overall (hazard ratio [HR], 0.59; 95%, CI 0.49 to 0.71) and colon cancer-specific (HR, 0.53; 95% CI, 0.43 to 0.66) mortality than the 488 (30.9%) who received 1 to 4 months of treatment. More than 30% of elderly patients who initiated FU-based c...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Jan 1, 1981·The New England Journal of Medicine·G Bonadonna, P Valagussa
May 5, 1994·The New England Journal of Medicine·W C WoodC R Ferree
Aug 23, 1993·Archives of Internal Medicine·R I Horwitz, S M Horwitz
Oct 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N WolmarkN J Petrelli
Jan 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J O'ConnellH S Wieand
Feb 12, 1998·Annals of Internal Medicine·D B Rubin
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M J O'ConnellA Figueredo
Sep 16, 1998·Clinical Therapeutics·R Balkrishnan
Feb 26, 1999·Journal of the National Cancer Institute·R T Vollmer
Apr 14, 1999·CA: a Cancer Journal for Clinicians·D M ParkinJ Ferlay
Jul 27, 1999·Journal of Hypertension·B WaeberG T McInnes
Aug 19, 1999·Journal of the National Cancer Institute·W Hryniuk
Jan 9, 2001·Journal of Clinical Epidemiology·C N KlabundeJ L Warren
Jun 8, 2001·Journal of the National Cancer Institute·D SchragC B Begg
Oct 2, 2001·CA: a Cancer Journal for Clinicians·R T GreenleeM Thun
Oct 13, 2001·The New England Journal of Medicine·D J SargentG Francini
Jan 5, 2002·European Journal of Clinical Pharmacology·J OkunoS Tomura
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vijaya SundararajanAlfred I Neugut
Mar 7, 2002·Medical Care·Elizabeth B LamontNicholas A Christakis
Jun 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rebecca A SillimanVincent Mor
Jul 23, 2002·JAMA : the Journal of the American Medical Association·Cynthia A JackeviciusJack V Tu
Aug 28, 2002·The Annals of Pharmacotherapy·Patrick J McDonnell, Michael R Jacobs
Nov 8, 2002·British Medical Bulletin·Peter Boyle, Maria Elena Leon
Dec 11, 2002·JAMA : the Journal of the American Medical Association·R Brian HaynesAmit X Garg
Jan 1, 2003·The Surgical Clinics of North America·Ernest T HawkJaye L Viner
Jan 14, 2003·The Journal of Clinical Psychiatry·Diana O Perkins
Feb 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ann H PartridgeJerry Avorn
Nov 25, 2003·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Joyce CramerUNKNOWN VA Naltrexone Study Group 425
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanJeffrey Crawford
Jun 4, 2004·The New England Journal of Medicine·Thierry AndréUNKNOWN Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC)
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aliza K FinkRebecca A Silliman
Sep 24, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanRichard I Fisher
Nov 30, 2004·Journal of General Internal Medicine·Rita MurriUNKNOWN AdICoNa Study Group

❮ Previous
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Citations

Mar 18, 2010·JAMA : the Journal of the American Medical Association·Katherine L KahnRobert H Fletcher
May 16, 2012·International Journal of Clinical Oncology·Masaichi OgawaKatsuhiko Yanaga
Feb 19, 2009·Journal of Cancer Survivorship : Research and Practice·A Marshall McBeanBeth A Virnig
Oct 17, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D PapamichaelUNKNOWN SIOG
Jan 5, 2010·Journal of Experimental & Clinical Cancer Research : CR·ZhenZhen ZhaoXianQing Jin
Jun 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dawn L HershmanAlfred I Neugut
Sep 4, 2012·Journal of Oncology Practice·Alfred I NeugutDawn L Hershman
Aug 28, 2012·The Oncologist·José A Serra-RexachMiguel Martín
Mar 17, 2007·Drugs & Aging·Hielke J Meulenbeld, Geert-Jan Creemers
May 24, 2011·Clinical Medicine Insights. Oncology·Joleen M HubbardDaniel J Sargent
Aug 29, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Guido R Zanni
Aug 21, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shigeru TatebeMasahide Ikeguchi
Mar 28, 2013·Journal of Women's Health·JoAnn S OliverMaria Pisu
Jan 19, 2010·Digestive Diseases and Sciences·Benjamin LebwohlAlfred I Neugut
Jan 16, 2010·Cancer Investigation·Benjamin LebwohlAlfred I Neugut
Feb 24, 2015·Gynecologic Oncology·Helen E DinkelspielJason D Wright
Sep 19, 2012·Seminars in Radiation Oncology·Jennifer Y WoLisa A Kachnic
Jan 5, 2016·Journal of Geriatric Oncology·Grant R WilliamsHolly Holmes
Jun 2, 2009·Cancer Treatment Reviews·Carlo AscheleSara Lonardi
Nov 28, 2008·Clinical Colorectal Cancer·Federica MerlinGiordano Domenico Beretta
Jul 16, 2008·Clinical Colorectal Cancer·Max S Mano, François Duhoux
Mar 4, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M KornmannK H Link
Oct 2, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FaivreA M Bouvier
Jul 1, 2015·Clinical Colorectal Cancer·Aalok KumarWinson Y Cheung
Nov 3, 2009·ANZ Journal of Surgery·Pierre H ChapuisOwen F Dent
Nov 29, 2015·Clinics in Geriatric Medicine·Joleen M Hubbard
Jul 16, 2008·International Journal of Cancer. Journal International Du Cancer·Keith I BlockCharlotte Gyllenhaal

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