Duration of binocular decorrelation in infancy predicts the severity of nasotemporal pursuit asymmetries in strabismic macaque monkeys.

Neuroscience
A HasanyLawrence Tychsen

Abstract

Strabismus in human infants is linked strongly to nasotemporal asymmetries of smooth pursuit, but many features of this co-morbidity are unknown. The purpose of this study was to determine how the duration of early-onset strabismus (or timeliness of repair) affects the severity of pursuit asymmetries in a primate model. Binocular image decorrelation was imposed on infant macaques by fitting them with prism goggles on day 1 of life. The goggles were removed after 3 weeks (n=2), 12 weeks (n=2) or 24 weeks (n=3), emulating surgical repair of strabismus in humans at 3, 12, and 24 months of age, respectively. Two control monkeys wore plano lenses. Several months after the goggles were removed, horizontal smooth pursuit was recorded using binocular search coils and a nasal-bias index (NBI) was calculated. Each animal in the 12- and 24-week groups developed a constant, alternating esotropic strabismus and a nasotemporal asymmetry of pursuit when viewing with either eye. Spatial vision was normal (no amblyopia). The 3-week duration monkeys were indistinguishable from control animals; they had normal eye alignment and symmetric pursuit. In the 12- and 24-week monkeys, the longer the duration of binocular decorrelation, the greater the p...Continue Reading

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Citations

Nov 10, 2013·Investigative Ophthalmology & Visual Science·Fatema Ghasia, Lawrence Tychsen
Dec 19, 2013·Investigative Ophthalmology & Visual Science·Mark M G WaltonMichael Mustari
Apr 23, 2011·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·H J Simonsz, G H Kolling
Jul 19, 2013·Journal of Ophthalmology·Fatema F Ghasia, Aasef G Shaikh
Apr 14, 2017·Journal of Neurophysiology·Mark M G WaltonKristina Tarczy-Hornoch
May 24, 2020·Investigative Ophthalmology & Visual Science·Adam Pallus, Mark M G Walton
Sep 13, 2018·Investigative Ophthalmology & Visual Science·Dinah ChenFatema F Ghasia
Jul 30, 2019·Physiological Reports·Seiji OnoTomohiro Kizuka

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