Duration of catalepsy correlates with increased intrastriatal sulpiride

European Journal of Pharmacology
H P HorikawaO Hikosaka

Abstract

To investigate the mechanism underlying sulpiride-induced catalepsy, we simultaneously examined cataleptic behavior and the kinetics of the dopamine receptor antagonist, sulpiride of dopamine, and the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), using in vivo voltammetry. After intrastriatal administration of sulpiride to freely moving rats, the levels increased, peaked at 20 min, and remained elevated for more than 3 h. Sulpiride-induced cataleptic behavior also continued for 3 h. Levels of DOPAC peaked 180 min after the injection and did not return to baseline within the experimental period. Thus, the time-course of cataleptic behavior correlated better with elevated extracellular levels of sulpiride than with that of DOPAC. These findings suggest that sulpiride induces catalepsy via a direct action.

References

Nov 8, 1988·European Journal of Pharmacology·A Imperato, G Di Chiara
Oct 1, 1988·Journal of Neurochemistry·T Nakazato, A Akiyama
Sep 28, 1984·Science·J W LangstonL S Forno
Aug 1, 1984·Journal of Pharmaceutical Sciences·F BressolleR Gomeni
Apr 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K OssowskaS Wolfarth

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