Duration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA)

The British Journal of Psychiatry : the Journal of Mental Science
J WhiteG D Batty

Abstract

The relationship between the duration of depressive symptoms and mortality remains poorly understood. To examine whether the duration of depressive symptoms is associated with mortality risk. Data (n= 9560) came from the English Longitudinal Study of Ageing (ELSA). We assessed depressive symptom duration as the sum of examinations with an eight-item Center for Epidemiologic Studies Depression Scale score of ⩾3; we ascertained mortality from linking our data to a national register. Relative to those participants who never reported symptoms, the age- and gender-adjusted hazard ratios for elevated depressive symptoms over 1, 2, 3 and 4 examinations were 1.41 (95% CI 1.15-1.74), 1.80 (95% CI 1.44-2.26), 1.97 (95% CI 1.57-2.47) and 2.48 (95% CI 1.90-3.23), respectively (Pfor trend <0.001). This graded association can be explained largely by differences in physical activity, cognitive function, functional impairments and physical illness. In this cohort of older adults, the duration of depressive symptoms was associated with mortality in a dose-response manner.

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Citations

Feb 28, 2017·Geriatrics & Gerontology International·Tomoyuki Kawada
May 10, 2017·International Journal of Alzheimer's Disease·Jindong Ding PetersenGunhild Waldemar
Jun 5, 2018·Psychosomatic Medicine·Yannick StephanAntonio Terracciano
Jan 18, 2019·Journal of the American Geriatrics Society·Renaud PéquignotJean-Philippe Empana
Sep 5, 2017·Diabetes & Metabolism Journal·Jong Hyun JeongUNKNOWN Task Force Team for Diabetes Fact Sheet of the Korean Diabetes Association
Aug 28, 2019·Population Studies·Emily M D GrundyHeini Väisänen
Apr 9, 2020·JAMA Psychiatry·Gemma ArcherMarcus Richards
Jan 11, 2019·Social Psychiatry and Psychiatric Epidemiology·Abdonas TamosiunasAnne Peasey
Jul 11, 2019·JAMA Network Open·Paola Zaninotto, Andrew Steptoe
Oct 5, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cesar de OliveiraJane P Biddulph
Jun 3, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Tomoyuki Kawada
Sep 3, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Vanessa P CorrêaIone J C Schneider
Jun 3, 2016·The British Journal of Psychiatry : the Journal of Mental Science·James WhiteG David Batty
Oct 7, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jessica G AbellPaola Zaninotto
Feb 13, 2021·British Dental Journal·Renato VenturelliRichard G Watt
Mar 27, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·J P SaadiD Cadar
Aug 24, 2021·International Psychogeriatrics·David D Ward, Ravi Bhat
Aug 28, 2021·Social Science & Medicine·Mark StevensKatherine J Reynolds
Oct 21, 2021·Acta Neuropsychiatrica·Miranda StiernborgAleksander A Mathé

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