Duration of effect of intravenous antibiotics on spirometry and sputum cytokines in children with cystic fibrosis

Pediatric Pulmonology
Steven CunninghamTom G Marshall

Abstract

Intravenous (IV) antibiotics are a mainstay of therapy in children with cystic fibrosis. It is unclear, however, over what period associated improvements in pulmonary function are maintained, and to what extent the underlying inflammatory process is impeded in children admitted for a course of IV antibiotics. This was a prospective, interventional study of 14 children (median age, 14 years; interquartile range, 10-14) with cystic fibrosis who were regular sputum producers and who required admission for a 2-week course of IV antibiotics. Children performed spirometry and provided a sputum sample prior to starting IV antibiotics and then weekly for 6 weeks, the first 2 weeks of which IV antibiotics were given. Sputum IL-8, TNF-alpha, IL-6, IL-10, MIP1-alpha, and elastase were measured. Seven children were asked to repeat the protocol in a subsequent exacerbation to assess similarities in response to therapy. Significant improvements were seen in forced expired volume in 1 sec (FEV(1)) in association with IV antibiotics (27% relative improvement in predicted from baseline to end of week 1, median FEV(1) 41.3% increasing to 52.2%), but this continued only 1 week following cessation of antibiotics. Although IL-8 demonstrated a trend...Continue Reading

References

Mar 1, 1991·Respiratory Medicine·R J RaynerD J Shale
Feb 1, 1991·Thorax·D NormanD J Shale
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Jan 1, 1995·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A SchusterV Wahn
Apr 1, 1995·American Journal of Respiratory and Critical Care Medicine·T Z KhanD W Riches
Jun 17, 1995·BMJ : British Medical Journal·D S ArmstrongP D Phelan
Dec 1, 1995·American Journal of Respiratory and Critical Care Medicine·T L BonfieldM Berger
Jan 1, 1996·Pediatric Pulmonology·P S SalvaC M Doerschuk
Mar 1, 1997·The Journal of Infectious Diseases·T L NoahM W Leigh
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·D Y KollerI Eichler
Jun 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C M SchneiderF D Daschner
Aug 1, 1997·Archives of Disease in Childhood·I M Balfour-LynnR Dinwiddie
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·L S NixonD J Shale
Mar 6, 1999·Clinical and Diagnostic Laboratory Immunology·J M WolterJ G McCormack
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·M S MuhlebachT L Noah
Oct 9, 1999·The European Respiratory Journal·S TakanashiK Okamura
Mar 15, 2000·Scandinavian Journal of Infectious Diseases·F KarpatiB Wretlind
Apr 26, 2000·The European Respiratory Journal·R A Stockley, D L Bayley
Oct 4, 2002·The European Respiratory Journal. Supplement·R DjukanovićF E Hargreave
Dec 4, 2002·The Journal of Pediatrics·Scott D SagelFrank J Accurso

❮ Previous
Next ❯

Citations

Dec 22, 2005·Journal of Sports Sciences·Brian W Timmons
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Brian W Timmons, Sandeep Raha
Aug 30, 2008·American Journal of Respiratory and Critical Care Medicine·Milene T SaavedraJerry A Nick
May 14, 2010·American Journal of Respiratory and Critical Care Medicine·Don B SandersChristopher H Goss
Jul 27, 2007·Proceedings of the American Thoracic Society·Scott D SagelMichael W Konstan
Dec 14, 2004·The American Journal of Medicine·Bruce K Rubin
Feb 24, 2006·The Journal of Pediatrics·Thomas FerkolCarlos E Milla
Jan 8, 2010·Pediatric Pulmonology·Don B SandersChristopher H Goss
Oct 7, 2005·Pediatric Pulmonology·David S ArmstrongKeith Grimwood
Jun 4, 2005·The Journal of Antimicrobial Chemotherapy·M O HussonB Wallaert
Mar 23, 2006·The Journal of Vascular Access·W D CarrollW Lenney

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.