PMID: 15247604Jul 13, 2004Paper

Duration of hepatitis B immunity in low risk children receiving hepatitis B vaccinations from birth

The Pediatric Infectious Disease Journal
Kenneth M PetersenAlan J Parkinson

Abstract

The duration of protection after hepatitis B vaccination of infants is unknown. We determined antibody to hepatitis B surface antigen (anti-HBs) at 4-13 years of age in 363 low risk children who had been vaccinated starting at birth with hepatitis B vaccine. Those with nonprotective titers (<10 mIU/mL) received a booster dose. We similarly followed 16 children of hepatitis B surface antigen (HBsAg)-positive mothers. Of low risk infants receiving a plasma-derived vaccine, 41% (42 of 102) of those whose primary response was unknown and 24% (4 of 17) who had initially responded retained protective titers (> or = 10 mIU/mL) of anti-HBs at 9 and 13 years, respectively. Of those who did not have protective antibody titers, 61% (33 of 54) and 67% (8 of 12), respectively, responded to a booster dose. In children of HBsAg-positive mothers, 31% retained protective anti-HBs at 12 years, and 90% (9 of 10) with nonprotective titers responded to a booster. In low risk children initially receiving a recombinant vaccine, 12.5% (26 of 208) and none (0 of 36) retained protective anti-HBs titers at 5 and 7 years of age, respectively. Of those who did not have protective titers, 90% (120 of 134) and 91% (32 of 35), respectively, responded to a boo...Continue Reading

References

Apr 28, 1989·JAMA : the Journal of the American Medical Association·R B WainwrightW L Heyward
Aug 1, 1994·The Pediatric Infectious Disease Journal·D J WestK Hedberg
Mar 1, 1997·The Journal of Infectious Diseases·R B WainwrightB J McMahon
Dec 11, 1997·The New England Journal of Medicine·W M Lee
Jun 13, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L R BulkowA J Parkinson
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M F YuenC L Lai
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L M HuangM H Chang
May 6, 1999·The Journal of Infectious Diseases·J S WuR P Beasley
Nov 24, 1999·JAMA : the Journal of the American Medical Association·D S LauderdaleR S Daum
Feb 11, 2000·The Journal of Infectious Diseases·R HarpazR B Wainwright
Aug 17, 2000·JAMA : the Journal of the American Medical Association·H R YusufL Rodewald
Sep 18, 2002·The Pediatric Infectious Disease Journal·Dexter SetoVirginia A Ioli

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Citations

Mar 27, 2013·Paediatric Drugs·Mona Abdel-Hady, Deirdre Kelly
Sep 9, 2005·The Pediatric Infectious Disease Journal·Catherine M DentingerAlan J Parkinson
Sep 9, 2005·The Pediatric Infectious Disease Journal·Colin W ShepardBeth P Bell
Sep 9, 2008·The Pediatric Infectious Disease Journal·Koen Van Herck, Pierre Van Damme
Aug 24, 2012·The Pediatric Infectious Disease Journal·Pavel TeoharovPierre Van Damme
Dec 20, 2012·The Pediatric Infectious Disease Journal·Katharina SchönbergerRüdiger V Kries
Jul 30, 2008·BMC Infectious Diseases·Cristina GiambiMarta L Ciofi degli Atti
May 20, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rita D ShethXianglin L Du
Aug 17, 2012·European Journal of Pediatrics·Cenk AypakSüleyman Görpelioğlu
Jan 26, 2010·Vaccine·Olivia J WhitePatrick G Holt
Feb 5, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Zeinab N A SaidIman I Salama
Nov 14, 2006·American Journal of Infection Control·Azza El SherbiniAbdel Hamid Abaza
Mar 24, 2017·Journal of Pediatric Gastroenterology and Nutrition·Abhishek WattsMarian D Pfefferkorn
May 3, 2005·Current Opinion in Infectious Diseases·Pier-Angelo TovoAntonia Versace
Aug 5, 2008·The Cochrane Database of Systematic Reviews·Joseph L MathewJesper Brok
Jul 9, 2014·Expert Review of Vaccines·Margaret A StanleyAnna R Giuliano
May 1, 2019·International Journal of Environmental Research and Public Health·Luca CoppetaAndrea Magrini
Jul 23, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shina Menon, Raj Munshi
Aug 10, 2020·Journal of Pediatric Hematology/oncology·Manal H El-SayedIman I Salama
Apr 20, 2021·Medical Journal, Armed Forces India·Dharmendra KumarReema Mukerjee

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