Duration of oral antibiotic therapy for the treatment of adult acne: a retrospective analysis investigating adherence to guideline recommendations and opportunities for cost-savings

Journal of the American Academy of Dermatology
Chelsey E StraightJoslyn S Kirby

Abstract

The duration of oral antibiotic acne therapy for adolescents compared with guidelines was recently investigated; however it was uncertain if duration of antibiotics for adult acne therapy differed. This study aimed to evaluate duration of oral antibiotics for adult acne compared with guidelines and determine possible cost-savings. This was a retrospective cohort study of MarketScan Commercial Claims and Encounters database that incorporated claims data to determine duration and costs of antibiotic treatment among adults ages 21 years and older. Of 17,448 courses, 84.5% (14,737) aligned with duration guidelines, although 12,040 (69.0%) courses did not include concomitant topical retinoid therapy. Mean savings of $592.26 per person could result if prolonged courses met guidelines. Mean (median) costs of generic and branded formulations for the most frequent course duration (90-179 days) were $103.77 ($54.27) and $1421.61 ($1462.25), respectively. Actual patient prescription adherence is uncertain and database lacks information regarding acne severity, patient physical characteristics, and clinical outcomes. The majority of oral antibiotic course durations follow guidelines, although topical retinoids are underused. Costs of antib...Continue Reading

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Citations

Jan 19, 2016·Journal of the American Academy of Dermatology·Reva BhushanAlan Menter
Jun 17, 2016·Dermatologic Therapy·Georgia Farrah, Ernest Tan
Jul 2, 2016·Dermatologic Clinics·Shelby HoppKarolyn A Wanat
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Jan 17, 2019·JAMA Dermatology·John S BarbieriDavid J Margolis
Mar 4, 2017·American Journal of Clinical Dermatology·Amanda BienenfeldSeth J Orlow
Jan 12, 2019·American Journal of Clinical Dermatology·Haoxiang Xu, Huiying Li
May 3, 2019·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Héctor C Pérez CelyHéctor J Castellanos Lorduy
Jan 13, 2021·Journal of the American Academy of Dermatology·Vaibhav GargJohn S Barbieri

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