Duration of ovarian hormone exposure and gynecological cancer risk in Korean women: the Korean Heart Study

Cancer Epidemiology
Keum Ji JungSun Ha Jee

Abstract

Although reproductive and hormonal factors - such as early menarche and late menopause - have been reported as independent risk factors for cancer, few studies have examined these factors in East Asian populations. We performed a large prospective cohort study of 66,466 women. Ovarian hormone exposure was defined as length of time between menarche and menopause. Incidence rates for breast, ovarian, endometrial and cervical cancers were examined separately in relation to reproductive lifespan defined as age at menopause minus age at menarche. Multivariable adjusted hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated using the Cox proportional hazards model. Women with early menarche were at increased risk for developing breast cancer (HR, 1.57, 95% CI, 1.17-2.10) for age at menarche ≤12 years compared to women with age at menarche ≥17 years. Women with late age at menopause (≥52 years) had increased risks for cancers of the breast (HR, 1.59, 95%CI, 1.11-2.28) and ovary (HR, 3.22, 95% CI, 1.09-9.55) compared to women with early menopause (≤45 years of age). Women with longer duration of ovarian hormone exposure (≥40 years) were at increased risk for developing breast cancer (HR, 2.23, 95% CI, 1.35-3.68) as...Continue Reading

References

Jun 1, 1996·QJM : Monthly Journal of the Association of Physicians·M J World
May 10, 2000·Maturitas·B L Harlow, L B Signorello
Jun 6, 2003·The New England Journal of Medicine·Ann S Hamilton, Thomas M Mack
Jun 9, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathryn L TerryKarin B Michels
Feb 15, 2008·Pediatrics·Mari S GolubJorma Toppari
Nov 20, 2009·International Journal of Cancer. Journal International Du Cancer·Laure DossusElio Riboli
Oct 4, 2011·Obstetrics and Gynecology Clinics of North America·Ellen B Gold
May 23, 2014·BMJ Open·Sun Ha JeeMark Woodward

❮ Previous
Next ❯

Citations

May 29, 2018·Annals of Human Biology·André O WerneckDanilo R Silva
Jul 6, 2019·BioMed Research International·Yanjun WuDongfeng Zhang
May 15, 2020·Clinical and Experimental Pediatrics·Ji Hyun Kim, Jung Sub Lim
Nov 11, 2020·Mayo Clinic Proceedings·Shin Chan KangJung Tak Park

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.