Duration of postoperative immunosuppression assessed by repeated delayed type hypersensitivity skin tests

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
J HammerH Kehlet


The duration of postoperative impairment in cell-mediated immunity was assessed by repeated skin testing with seven delayed type common antigens in 15 patients undergoing major elective abdominal surgery compared to a similar testing regimen in 10 healthy volunteers. All were skin tested four times, with 72-hour intervals, and in the surgical patients the first test was applied 2 days before surgery, followed by tests on postoperative days 1, 4 and 7. The tests were read after 48 h. Postoperatively, the skin test area decreased on day 3 (p less than 0.01) and recurred to preoperative levels on day 9. In contrast, the skin test area in the volunteers increased from test to test (p less than 0.001) during the study, confirming a previous finding of a vaccination effect. These results suggest that the postoperative immunosuppression is maintained for about 6-9 days.


May 1, 1995·Diseases of the Colon and Rectum·L B SvendsenB H Sparsø
Jun 27, 2002·Current Urology Reports·I Y Kim, P G Schulam
Sep 2, 1998·The Annals of Thoracic Surgery·S R CraigW S Walker
Apr 30, 1999·Allergy·G T KampenL J Petersen
Jul 11, 2013·Future Oncology·Zhang PengjunTian Yaping
Feb 2, 2010·Surgery·William N SouthernLawrence J Brandt
May 16, 2006·Thoracic Surgery Clinics·Ryan C Fields, Bryan F Meyers
Dec 28, 2004·The Surgical Clinics of North America·Patricia SyllaRichard L Whelan
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·H Kehlet, F Moesgaard
Feb 27, 1999·Scandinavian Journal of Gastroenterology·R Beier-Holgersen, B Brandstrup
May 1, 1995·The British Journal of Surgery·H J Nielsen
Feb 6, 1999·Critical Care Medicine·S ZedlerE Faist
Nov 1, 1996·The British Journal of Surgery·L N JorgensenF Gottrup
Apr 9, 1999·Anesthesia and Analgesia·C D Spies, H Rommelspacher

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.