Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer

The New England Journal of Medicine
D BergqvistENOXACAN II Investigators

Abstract

Abdominal surgery for cancer carries a high risk of venous thromboembolism, but the optimal duration of postoperative thromboprophylaxis is unknown. We conducted a double-blind, multicenter trial in which patients undergoing planned curative open surgery for abdominal or pelvic cancer received enoxaparin (40 mg subcutaneously) daily for 6 to 10 days and were then randomly assigned to receive either enoxaparin or placebo for another 21 days. Bilateral venography was performed between days 25 and 31, or sooner if symptoms of venous thromboembolism occurred. The primary end point with respect to efficacy was the incidence of venous thromboembolism between days 25 and 31. The primary safety end point was bleeding during the three-week period after randomization. The patients were followed for three months. The intention-to-treat analysis of efficacy included 332 patients. The rates of venous thromboembolism at the end of the double-blind phase were 12.0 percent in the placebo group and 4.8 percent in the enoxaparin group (P=0.02). This difference persisted at three months (13.8 percent vs. 5.5 percent, P=0.01). Three patients in the enoxaparin group and six in the placebo group died within three months after surgery. There were no ...Continue Reading

References

Mar 23, 1991·BMJ : British Medical Journal·B LindbladD Bergqvist
Jul 2, 1988·BMJ : British Medical Journal·J H ScurrJ H Hasty
Feb 1, 1985·The British Journal of Surgery·D Bergqvist, B Lindblad
Feb 7, 2001·Chest·W H GeertsH B Wheeler
Mar 27, 2001·The Journal of Bone and Joint Surgery. American Volume·P C CompUNKNOWN Enoxaparin Clinical Trial Group
May 6, 2006·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·D Bergqvist, B Jönsson

❮ Previous
Next ❯

Citations

Jan 16, 2007·Internal and Emergency Medicine·Walter Ageno, Alessandro Squizzato
Jan 16, 2007·Internal and Emergency Medicine·Michela FalcianiDomenico Prisco
Nov 18, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Lee NewkirkErnest Conrad
Jan 29, 2011·International Journal of Colorectal Disease·Paulus Menno VerheijenJohn W Lumley
Jan 17, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Wolfgang Korte
Jul 6, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Makoto SakaHitoshi Katai
Oct 17, 2006·Diseases of the Colon and Rectum·Thomas J StahlUNKNOWN Standards Practice Task Force of The American Society of Colon and Rectal Surgeons
Oct 5, 2006·Diseases of the Colon and Rectum·David Bergqvist
Nov 10, 2009·Wiener medizinische Wochenschrift·Sabine Eichinger
Oct 2, 2007·Journal of Thrombosis and Thrombolysis·Agnes Yuet Ying Lee
Dec 27, 2008·Journal of Thrombosis and Thrombolysis·Abeer A ZeitounMarwan G Akel
May 30, 2009·Journal of Thrombosis and Thrombolysis·Alex C SpyropoulosDavid Battleman
Nov 6, 2009·Journal of Thrombosis and Thrombolysis·Gregory Piazza, Samuel Z Goldhaber
Nov 17, 2009·Journal of Thrombosis and Thrombolysis·Dale W Bratzler
Jan 5, 2011·Journal of Thrombosis and Thrombolysis·Sheryl J HernerThomas G Vondracek
Mar 2, 2011·Journal of Thrombosis and Thrombolysis·Alexander Thomas CohenVictor Tapson
Feb 19, 2011·Journal of Thrombosis and Thrombolysis·Michael B Streiff
May 10, 2011·Journal of Thrombosis and Thrombolysis·J E Stark, W J Smith
Jun 15, 2011·Journal of Thrombosis and Thrombolysis·Kenneth C Wilson, Geno J Merli
Jun 22, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Srinevas K ReddyDavid A Geller
Jun 1, 2011·Obesity Surgery·Kimberley Eden SteeleThomas H Magnuson
Dec 31, 2003·Current Treatment Options in Oncology·Leno ThomasMartin J Edelman
Oct 23, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Miriam López-GómezManuel González Barón
Aug 9, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Andrés J MuñozDolores Isla
Nov 26, 2013·Best Practice & Research. Clinical Anaesthesiology·Kate Burbury
May 19, 2005·Disease-a-month : DM·Joseph A Caprini
Jul 9, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Feras Abu SaadehNoreen Gleeson
Feb 25, 2005·Gastrointestinal Endoscopy·Marc J ZuckermanUNKNOWN Standards of Practice Committee of the American Society for Gastrointestinal Endoscopy
Jul 31, 2003·Cancer Treatment Reviews·Morten S Rasmussen
Apr 27, 2005·Asian Journal of Surgery·Subhita PrasannanYunus A Gul
Oct 31, 2003·Critical Reviews in Oncology/hematology·Mario MandalàSandro Barni
Jun 1, 2005·The Lancet Oncology·Paolo PrandoniAndrea Piccioli
Oct 30, 2008·Nature Clinical Practice. Oncology·Marc Carrier, Agnes Y Y Lee
Feb 2, 2010·Clinics in Colon and Rectal Surgery·Michael P McNally, Christopher J Burns
Jul 19, 2002·The New England Journal of Medicine·Sophie MouliasSylvie Meaume
Dec 31, 2010·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Rosario VecchioEva Intagliata
Jun 30, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A A Khorana
Oct 16, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N KucherH Bounameaux
Oct 20, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MandalàUNKNOWN ESMO Guidelines Working Group
Aug 13, 2002·Current Opinion in Pulmonary Medicine·Graham F Pineo, Russell D Hull

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.