Duration of smoking cessation and its impact on skin flap survival

Plastic and Reconstructive Surgery
Jeffrey V ManchioAdam J Vernadakis

Abstract

Empirical and experimental evidence abounds as to the negative effects of smoking on skin flaps. The ideal duration of preoperative smoking cessation is unclear. The present study evaluates the effect of various durations of smoking cessation on skin flap survival in a rat model. Forty smoke-exposed and 10 non-smoke-exposed Sprague-Dawley rats were divided into five groups: controls and 0 days, 2 weeks, 4 weeks, and 8 weeks of smoking cessation. All animals had a dorsally based random pattern flap created and either bilateral pure axial superficial inferior epigastric (superficial inferior epigastric) flaps or a unilaterally superficial inferior epigastric axial with random component flap. The percentage of flap necrosis was assessed 2 weeks postoperatively. The mean amount of random skin flap necrosis was 16.6 +/- 13.0 percent, 30.3 +/- 8.4 percent, 27.6 +/- 7.9 percent, 27.1 +/- 6.1 percent, and 29.7 +/- 10.3 percent, respectively. There was significantly less flap necrosis in the controls than in all other groups (p < 0.03). There was no necrosis of any of the pure axial superficial inferior epigastric flaps. The mean amount of superficial inferior epigastric axial with random component skin flap necrosis was 11.1 +/- 6.2 pe...Continue Reading

References

Mar 1, 1978·Plastic and Reconstructive Surgery·F Finseth, C Cutting
Apr 1, 1978·Plastic and Reconstructive Surgery·L H MoselyM Goody
Jul 15, 1992·The American Journal of Medicine·P Silverstein
Aug 1, 1992·Plastic and Reconstructive Surgery·R M Dunn, J Mancoll
Mar 1, 1992·Plastic and Reconstructive Surgery·W F ReusD J Straker
Jul 1, 1991·Archives of Dermatology·D Goldminz, R G Bennett
Oct 1, 1988·Annals of Plastic Surgery·M Westin, P Hedén
Apr 1, 1985·Plastic and Reconstructive Surgery·J NolanR C Schultz
Jun 1, 1985·Plastic and Reconstructive Surgery·S Craig, T D Rees
Sep 1, 1984·Plastic and Reconstructive Surgery·J J Petry, K A Wortham
Apr 1, 1984·British Journal of Plastic Surgery·W T LawrenceJ P Heggers
Jun 1, 1984·Plastic and Reconstructive Surgery·T D ReesC L Guy
Jan 1, 1996·Plastic and Reconstructive Surgery·L N van AdrichemJ C van der Meulen
Mar 10, 1998·Human & Experimental Toxicology·C J SmithJ H Robinson
Mar 21, 1998·Plastic and Reconstructive Surgery·R J RohrichS E Copit
Jun 9, 2000·Plastic and Reconstructive Surgery·D W ChangS S Kroll
Sep 8, 2001·Plastic and Reconstructive Surgery·S L Spear
Feb 1, 1965·Plastic and Reconstructive Surgery·R M MCFARLANER A HENRY
Dec 6, 2005·Plastic and Reconstructive Surgery·Scott L SpearCatherine Hannan

❮ Previous
Next ❯

Citations

Mar 3, 2011·Plastic and Reconstructive Surgery·Katrin SeidenstueckerChristoph Andree
Oct 12, 2012·Annals of Surgical Oncology·Fabio SantanelliGuido Paolini
Mar 29, 2016·The Breast : Official Journal of the European Society of Mastology·Katrin SeidenstueckerPhillip N Blondeel
Apr 2, 2013·The Kaohsiung Journal of Medical Sciences·Jian-Xun ChenPin-Keng Shih
Sep 17, 2013·The Surgical Clinics of North America·Robert G Martindale, Clifford W Deveney
Feb 22, 2012·International Journal of Dermatology·Arisa Ortiz, Sergei A Grando
Dec 3, 2014·Annales de chirurgie plastique et esthétique·I PluvyB Chaput
Oct 23, 2018·JAMA Facial Plastic Surgery·Chelsea TroianoJeffrey H Spiegel
Jun 26, 2015·Plastic and Reconstructive Surgery·Edward M ReeceLloyd Champagne
May 24, 2013·Journal of the American Podiatric Medical Association·Crystal L RamanujamThomas Zgonis
Jun 16, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Zaroug JaleelJeffrey Spiegel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.