Duration of testosterone suppression after a 9.45 mg implant of the GnRH-analogue buserelin in patients with localised carcinoma of the prostate a 12-month follow-up study

European Urology
Bill PetterssonJ Sandow

Abstract

(1) To determine the duration of androgen deprivation after a single buserelin implant 9.45 mg in the neoadjuvant setting in combination with curative radiation therapy of carcinoma of the prostate, and (2) to evaluate the time to recovery of gonadal function, and the incidence and duration of hypogonadal symptoms. We prospectively evaluated 21 men with carcinoma of the prostate who received one implant of 9.45 mg buserelin subcutaneously. Release of buserelin, changes in serum testosterone concentration, hot flushing and sexual function over a 12-month study period were recorded. Testosterone was suppressed below the castration limit (0.58 ng/ml=2 nmol/l) for 224 days (range, 139-309). The mean time to first return of testosterone above the castration limit was 246 days (range, 168-344); 50% of pre-treatment value was reached after 285 days (range, 218-370). The prevalence of hot flushing was 19 of 21 patients (90%) at 12 weeks. At the end of the study period, serum testosterone had reached 80% (range, 33%-166%) of pre-treatment concentration, sexual interest was present in 52%, erection was possible in 60%, and hot flushing remained in 24%. A single injection of 3-month buserelin implant 9.45 mg suppresses serum testosterone ...Continue Reading

References

May 1, 1992·British Journal of Urology·R J ShearerD P Dearnaley
Dec 15, 1993·Cancer·K Griffiths
Jul 18, 2001·The Journal of Urology·A C SpetzUNKNOWN Scandinavian Prostatic Cancer Group-5 Trial Study
Mar 20, 2002·Cancer·Tom PicklesUNKNOWN British Columbia Cancer Agency, Prostate Cohort Outcomes Initiative
Jul 28, 2005·European Urology·G AusUNKNOWN European Association of Urology

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Citations

Mar 15, 2008·European Urology·Jacques IraniUNKNOWN Association for Research in Urological Oncology
Nov 18, 2020·Advanced Drug Delivery Reviews·Christian Isalomboto NkangaFarshad Ramazani
Nov 13, 2018·International Journal of Radiation Oncology, Biology, Physics·Daphna Y SpiegelBridget F Koontz

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