Duration of the action of rocuronium in patients with BMI of less than 25: An observational study

European Journal of Anaesthesiology
Osamu TakahataTakayuki Kunisawa

Abstract

The duration of rocuronium in patients with BMI more than 30 kg m is prolonged. Whether the reverse is true when BMI is less than 18.5 kg m is unclear. The objective of this study was to investigate whether a BMI less than 25 kg m affects the duration of rocuronium in doses adjusted for actual body weight. A prospective, observational, single-centre study. The operating room of a teaching hospital from 1 June 2008 to 30 June 2015. Thirty patients with American Society of Anesthesiologists physical status I or II who were scheduled to undergo elective surgery (BMI < 25 kg m, aged 23 to 74 years) maintained by 0.7 minimum alveolar concentration sevoflurane and remifentanil. Repetitive train-of-four stimulation was applied and contractions of the adductor pollicis muscle were recorded. Duration of the initial dose of rocuronium (D1) was defined as the time from injection of rocuronium 0.6 mg kg to return of first twitch height to 25% of the control. Duration of additional doses (D2) was the time from a supplement of 0.15 mg kg rocuronium to return of first twitch height to 25% of the control. The relationship between D1 or D2 and BMI was examined using linear regression analysis. Linear regression analysis revealed a significant c...Continue Reading

References

Feb 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D R BevanF Donati
Mar 24, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C Motamed, F Donati
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Jul 20, 2007·Acta Anaesthesiologica Scandinavica·T Fuchs-BuderUNKNOWN 8th International Neuromuscular Meeting
Mar 7, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Masafumi FujimotoTatsuo Yamamoto

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