Duration of untreated negative symptoms and duration of active negative symptoms: proof of concepts

Early Intervention in Psychiatry
Brendan P MurphyP D McGorry


Negative symptoms are responsible for enormous burden in schizophrenia; yet they remain under-recognized and under-treated. There is mounting evidence that early intervention is crucial and that response to treatment falls away with chronicity. Current measures of illness duration fail to adequately capture the true time course of negative symptoms and new concepts are required to correct this and to focus clinical attention. The aim of this paper is to introduce accurate measures of negative symptom duration. Two new concepts, the duration of untreated negative symptoms (DUNS) and the duration of active negative symptoms (DANS), were trialled in a first-episode sample with primary negative symptoms. The new measures were easy to calculate and more accurately reflected the total duration of negative symptoms than currently available measures. The mean duration of untreated psychosis was 23 weeks, whereas the DUNS was 93.79 weeks. Applicability of the concepts needs confirming by replication with a larger cohort. Introduction of these concepts may have widespread implications for the timely and efficient treatment of negative symptoms and the reduction of the total burden of illness of schizophrenia within society.


Sep 1, 1992·The American Journal of Psychiatry·A D LoebelS R Szymanski
Nov 1, 1991·Archives of General Psychiatry·W S Fenton, T H McGlashan
Dec 1, 1986·Journal of Clinical Psychopharmacology·H Y MeltzerD J Luchins
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Dec 1, 1994·The American Journal of Psychiatry·J A LiebermanJ M Kane
Oct 1, 1994·The American Journal of Psychiatry·D I MayerhoffJ A Lieberman
Jan 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·H HäfnerA Riecher-Rössler
Jan 1, 1996·Schizophrenia Bulletin·A R Yung, P D McGorry
Sep 2, 1998·Psychological Medicine·P D McGorryH J Jackson
Apr 22, 1999·Psychiatric Services : a Journal of the American Psychiatric Association·F B DickersonF Parente
Feb 2, 2000·European Archives of Psychiatry and Clinical Neuroscience·H Häfner, W an der Heiden
Oct 3, 2000·Psychiatric Services : a Journal of the American Psychiatric Association·A BreierW T Carpenter
Sep 5, 2002·Psychiatry Research·Eva M MeisenzahlHans-Jürgen Möller
Feb 26, 2004·Psychological Medicine·J AddingtonD Addington
Mar 24, 2004·Schizophrenia Research·Todd LenczBarbara Cornblatt
Jul 12, 2005·Schizophrenia Research·Meredith G HarrisPatrick D McGorry
Dec 14, 2005·The Australian and New Zealand Journal of Psychiatry·Alison R YungJoe Buckby
Jun 15, 2006·Cellular and Molecular Neurobiology·Joseph T Coyle
Aug 26, 2006·Schizophrenia Research·Brendan P MurphyPatrick D McGorry
Oct 7, 2006·Acta Psychiatrica Scandinavica·Stephen M Stahl
Oct 27, 2006·Human Psychopharmacology·Brendan P MurphyPatrick D McGorry

❮ Previous
Next ❯


May 28, 2010·International Review of Psychiatry·Brendan P Murphy
Mar 26, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·J LyneM Clarke
Jan 15, 2015·Early Intervention in Psychiatry·John LyneAshok Malla
Oct 26, 2018·Harvard Review of Psychiatry·Geneviève SauvéMartin Lepage
Aug 11, 2018·Social Psychiatry and Psychiatric Epidemiology·Srividya IyerAshok Malla

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.