During development, 17alpha-estradiol is a potent estrogen and carcinogen

Environmental Health Perspectives
R A HajekL A Jones

Abstract

Neonatal administration of estradiol-17beta (E2-17beta) increases the nuclear DNA content in the mouse reproductive tract. Similar responses have been demonstrated for synthetic estrogens such as diethylstilbestrol. One of the questions raised regarding environmental estrogens such as organochlorines is whether they are potent enough to result in abnormal changes such as those demonstrated by both natural and synthetic estrogens. To test this hypothesis, female BALB/c mice were treated neonatally (days 1-5) with either E2-17beta or estradiol-17alpha (E2-17alpha), an inactive stereoisomer in adult reproductive tissues. We also proposed whether neonatal administration of (E2-17alpha) was tumorigenic and whether the effects were age dependent. To answer these questions, one set each of 10 day-old treated and control mice received short-term secondary administration of E2-17beta, E2-17alpha, or cholesterol. Cervicovaginal tracts from intact BALB/c mice were examined histologically and by flow cytometry at 70 days of age and by histology alone at 18 to 22 months of age. The results include several important findings: a) like E2-17beta, neonatal E2-17alpha treatment induced persistent vaginal cornification, hypospadias, vaginal concr...Continue Reading

References

Oct 1, 1978·Endocrinology·R K Tcholakian, A Steinberger
Oct 24, 1992·Lancet·A EkbomS J Lan
Jan 1, 1992·Critical Reviews in Oncology/hematology·R ClarkeM E Lippman
May 1, 1990·Mutation Research·J G Liehr
Jan 1, 1989·Teratogenesis, Carcinogenesis, and Mutagenesis·K Hillbertz-Nilsson, J G Forsberg
Oct 1, 1988·Molecular Endocrinology·D S Loose-MitchellG M Stancel
Aug 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N FisherA V Ginocchio
Oct 1, 1995·Scientific American·D L Davis, H L Bradlow
Apr 21, 1993·Journal of the National Cancer Institute·M S WolffN Dubin
Oct 1, 1995·Environmental Health Perspectives·L A Jones, R A Hajek
Jan 1, 1996·Psychotherapy and Psychosomatics·P Høglend

❮ Previous
Next ❯

Citations

Jul 28, 1999·Environmental Health Perspectives·R BigsbyF S vom Saal
Jul 11, 2001·Environmental Health Perspectives·D AxelrodL A Jones
Jul 27, 2005·Reproductive Biology and Endocrinology : RB&E·Mercedes Perusquía, Erika Navarrete
Aug 5, 2005·Environmental Health Perspectives·Jeanelle M MartinezLovell A Jones
Sep 19, 2019·Connective Tissue Research·Dave EwartRichard F Loeser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.