Durvalumab-associated vasculitis presenting as 'the blue toe syndrome'

BMJ Case Reports
Shivangi GuptaDavid Prentice

Abstract

Durvalumab is a selective, high-affinity human immunoglobulin monoclonal antibody in a class called check point inhibitors, that blocks PD-L1 on tumour cells. Despite clinical success in increasing progression-free survival rates in patients with stage III non-small-cell lung cancer, durvalumab has been associated with immune-related side effects such as pneumonitis and colitis. We present a case of an 84-year-old woman with acral vasculitis presenting as blue toe syndrome, associated with prolonged use of durvalumab. After 1 year of fortnightly durvalumab therapy postchemoradiation therapy, the patient came in with a left blue big toe, and later developed bilateral livedo racemosa. The diagnosis of durvalumab-associated vasculitis was made and treatment with prednisolone was started with clinical improvement.

References

Nov 1, 1976·Archives of Surgery·A M KarmodyR P Leather
Oct 7, 2008·Nature Medicine·Renate KainDontscho Kerjaschki
Dec 24, 2008·Journal of the American Academy of Dermatology·Jan V Hirschmann, Gregory J Raugi
Dec 8, 2010·International Journal of Clinical Oncology·Pieter G PostemaDick J Richel
Aug 3, 2012·Acta Dermato-venereologica·Tamihiro KawakamiYoshinao Soma
Jan 25, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hui ZhangCornelia M Weyand
Sep 9, 2017·The New England Journal of Medicine·Scott J AntoniaUNKNOWN PACIFIC Investigators
Nov 22, 2017·BMJ Case Reports·Ami Schattner
Jun 21, 2018·Clinical Rheumatology·Anisha DaxiniAntoine G Sreih
Jun 30, 2018·Expert Review of Respiratory Medicine·Laura Mezquita, David Planchard
Jul 18, 2018·Drug Design, Development and Therapy·Hui YangXuelei Ma
Nov 18, 2018·Journal for Immunotherapy of Cancer·Thibault ComontOdile Beyne-Rauzy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Scott J Antonia, Mustafa Özgüroğlu
The New England Journal of Medicine
Matteo SantoniSebastiano Buti
The New England Journal of Medicine
Mehmet D CopurRyan Ramaekers
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Antoine DesiletsArielle Elkrief
Case Reports in Ophthalmology
Antonio R AndradeJose García-Arumí
© 2021 Meta ULC. All rights reserved