Durvalumab-induced Immune-related Hepatitis in a Patient with Non-small Cell Lung Cancer.

Internal Medicine
Masakatsu NakamuraTomiyasu Arisawa

Abstract

We herein report the case of a 79-year-old patient with unresectable stage III non-small cell lung cancer who developed immune-related hepatitis caused by durvalumab administration. Durvalumab was administered at 10 mg/kg every two weeks after the treatment with carboplatin (AUC2), paclitaxel (35 mg/m2), and 60 Gy radiation. At the day 208 in which the 14th durvalumab administration was scheduled, the patient was urgently hospitalized due to CTCAE Grade 4 hepatic dysfunction detected during the an outpatient blood sampling test. He was diagnosed with immune-related hepatitis and started on methylprednisolone 60 mg/day. After 51 days, his liver dysfunction improved and he was discharged.

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Citations

Nov 12, 2020·Pharmaceuticals·Nicola J NasserAbed Agbarya

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Methods Mentioned

BETA
X-ray
biopsy

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