Dust related risks of clinically relevant lung functional deficits.

Occupational and Environmental Medicine
H A CowieC A Soutar

Abstract

To quantify the risks of clinically important deficits of FEV1 in coal miners in relation to cumulative and average concentrations of respirable dust. Data were studied from over 7000 men who had been surveyed in the late 1970s. Linear regression equations for the association between FEV1 and self-reported breathlessness on mild exertion were used to define clinically important levels of FEV1 deficit, and the probabilities that individuals with different dust exposures would experience these deficits were calculated. Levels of FEV1 were lower among breathless men than among others, with a large overlap of the distributions. The relations between standardised FEV1 and breathlessness were constant over all age and smoking groups. A decrease of 100 ml in FEV1 was associated with an increase of 1.12 in the odds of reporting breathlessness. FEV1 deficits of -0.367, -0.627, and -0.993 l (designated as "small", "medium", and "large" deficits) were, on average, associated with proportional increases of risks of breathlessness by factors of 1.5, 2.0, and 3.0 respectively. Cumulative respirable dust exposure ranged up to 726 gh/m3, mean 136 gh/m3 (British Medical Research Council measurement convention). An increase of 50 gh/m3 was assoc...Continue Reading

References

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Citations

Aug 31, 2010·American Journal of Respiratory and Critical Care Medicine·Mark D EisnerUNKNOWN Committee on Nonsmoking COPD, Environmental and Occupational Health Assembly
Dec 27, 2008·Sangyō eiseigaku zasshi = Journal of occupational health·Yasuo MorimotoYoshiharu Aizawa
Jun 5, 2010·Journal of Occupational and Environmental Medicine·George Van HoutvenEric Finkelstein

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