Dutch randomized trial comparing standard catheter-directed thrombolysis and ultrasound-accelerated thrombolysis for arterial thromboembolic infrainguinal disease (DUET)

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
A M SchrijverJ P P De Vries

Abstract

To report the results of the Dutch randomized trial comparing standard catheter-directed and ultrasound-accelerated thrombolysis (UST) for the treatment of arterial thromboembolic occlusions. The DUET study ( controlled-trials.com ; identifier ISRCTN72676102) was designed to assess whether UST can reduce therapy time significantly compared with standard thrombolysis (ST). Sixty patients (44 men; mean age 64 years) with recently (7-49 days) thrombosed infrainguinal native arteries or bypass grafts causing acute limb ischemia (Rutherford category I or IIa) were randomized to ST (n = 32) or UST (n = 28). The primary outcome was the duration of thrombolysis needed for uninterrupted flow (> 95% thrombus lysis), with outflow through at least 1 below-the-knee artery. Continuous data are presented as means ± standard deviations. Thrombolysis was significantly faster in the UST group (17.7 ± 2.0 hours) than in the ST group (29.5 ± 3.2 hours, p = 0.009) and required significantly fewer units of urokinase (2.8 ± 1.6 × 10(6) IU in the ST group vs. 1.8 ± 1.0 × 10(6) IU in the UST group, p = 0.01) for uninterrupted flow. Technical success was achieved in 27 (84%) patients in the ST group vs. 21 (75%) patients in the UST group (p = 0.52). The...Continue Reading

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Citations

Feb 7, 2017·Therapeutic Advances in Cardiovascular Disease·Sotirios GiannakakisChrisostomos Maltezos
Mar 17, 2015·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Nicolas W Shammas
Aug 11, 2018·The Cochrane Database of Systematic Reviews·Rosemary DarwoodRachel Forster
Aug 31, 2018·Minerva cardioangiologica·Frantisek StanekDavid Prochazka
Aug 17, 2019·Journal of Clinical Medicine·Dan-Mircea OlinicMaria Olinic
Apr 20, 2018·Vascular and Endovascular Surgery·Alessandro CannavaleFabrizio Fanelli
Feb 8, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Kak Khee Yeung, M S Conte
Oct 27, 2020·The International Journal of Angiology : Official Publication of the International College of Angiology, Inc·Balaji NatarajanAshis Mukherjee
Apr 2, 2021·Critical Care Nurse·Sara Knippa, Shannon Vernon
Jul 26, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Sabrina A N DoelareUNKNOWN MUST collaborators
Apr 22, 2019·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Harm P EbbenKak K Yeung

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Methods Mentioned

BETA
percutaneous transluminal angioplasty
amputation
amputations

Clinical Trials Mentioned

ISRCTN72676102

Software Mentioned

SPSS

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