DW-MRI and DCE-MRI are of complementary value in predicting pathologic response to neoadjuvant chemoradiotherapy for esophageal cancer

Acta Oncologica
Sophie E HeethuisAstrid L H M W van Lier

Abstract

To explore the potential benefit and complementary value of a multiparametric approach using diffusion-weighted (DW-) and dynamic contrast-enhanced (DCE-) magnetic resonance imaging (MRI) for prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. Forty-five patients underwent both DW-MRI and DCE-MRI prior to nCRT (pre), during nCRT (week 2-3) (per) and after completion of nCRT, but prior to esophagectomy (post). Subsequently, histopathologic tumor regression grade (TRG) was assessed. Tumor apparent diffusion coefficient (ADC) and area-under-the-concentration time curve (AUC) were calculated for DW-MRI and DCE-MRI, respectively. The ability of these parameters to predict pathologic complete response (pCR, TRG1) or good response (GR, TRG ≤ 2) to nCRT was assessed. Furthermore the complementary value of DW-MRI and DCE-MRI was investigated. GR was found in 22 (49%) patients, of which 10 (22%) patients showed pCR. For DW-MRI, the 75th percentile (P75) ΔADCpost-pre was most predictive for GR (c-index = 0.75). For DCE-MRI, P90 ΔAUCper-pre was most predictive for pCR (c-index = 0.79). Multivariable logistic regression analyses showed complementary value when combining DW-MRI and DCE-MRI for pCR prediction ...Continue Reading

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Citations

Jun 21, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Yang ZhouZi-Xiang Kuai
Mar 27, 2019·British Journal of Cancer·Laura BeatonRicky A Sharma
Jun 24, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Sophie E VollenbrockAnnemarieke Bartels-Rutten
Nov 23, 2019·Magnetic Resonance Imaging Clinics of North America·Francesco De CobelliFrancesco Giganti
Feb 16, 2021·Frontiers in Oncology·Petra J van HoudtUulke A van der Heide
Sep 6, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Maria J ValkemaRoelf Valkema
Apr 9, 2021·Frontiers in Oncology·Sangjune Laurence LeeStella Mook
Sep 29, 2019·European Journal of Radiology·Chloé LeandriMaximilien Barret

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