DXS10011: studies on structure, allele distribution in three populations and genetic linkage to further q-telomeric chromosome X markers

International Journal of Legal Medicine
Sandra HeringReinhard Szibor

Abstract

The hypervariable tetranucleotide STR polymorphism DXS10011 is a powerful marker for forensic purposes. Investigation of this STR led to an allele nomenclature which is in consensus with the ISFG recommendations. DXS10011 is located at Xq28 and genetically closely linked to DXS7423 and DXS8377 but is unlinked to HPRTB and more distant X-chromosomal STRs. DXS10011 is a very complex marker exhibiting some structural variants within alleles of identical length. Two types of repeat structure (regular and inter-alleles) are known and described as types A and B. Two SNPs which are in strong linkage disequilibrium to the different sequence types were found in the repeat flanking region. The type A sequence consists of a long stretch of uninterrupted homogenous repeats which is highly susceptible to slippage mutation during male meiosis.

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Dec 3, 2003·Forensic Science International : Synergy·Reinhard SziborMatthias Michael

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Citations

Feb 14, 2006·International Journal of Legal Medicine·H AsamuraH Fukushima
Aug 13, 2005·International Journal of Legal Medicine·Reinhard SziborJeanett Edelmann
Jun 8, 2006·International Journal of Legal Medicine·H AsamuraH Fukushima
Nov 26, 2009·International Journal of Legal Medicine·Sandra HeringReinhard Szibor
Mar 16, 2011·International Journal of Legal Medicine·Elzemar Martins Ribeiro-RodriguesSidney Santos
Oct 16, 2012·Molecular Biology Reports·Guo-Lian YuanBofeng Zhu
May 28, 2005·Forensic Science International : Synergy·Micaela PoetschEberhard Lignitz
May 30, 2009·Croatian Medical Journal·Eun Jin LimKyoung-Jin Shin
Dec 6, 2005·International Journal of Legal Medicine·Maria T ZarrabeitiaJose A Riancho
Jan 25, 2011·Forensic Science International. Genetics·Sylwia ŁuczakTomasz Grzybowski
Dec 17, 2008·Forensic Science International. Genetics·Elzemar Martins Ribeiro RodriguesSidney Emanuel Batista dos Santos
Dec 17, 2008·Forensic Science International. Genetics·Jeanett EdelmannReinhard Szibor
Dec 17, 2008·Forensic Science International. Genetics·Dorit BeckerWerner Brabetz
Jun 1, 2007·Forensic Science International. Genetics·Reinhard Szibor
Oct 12, 2005·Forensic Science International : Synergy·Micaela PoetschEberhard Lignitz

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