Dye-doped biodegradable nanoparticle SiO2 coating on zinc- and iron-oxide nanoparticles to improve biocompatibility and for in vivo imaging studies

Nanoscale
Elena Navarro-PalomaresRafael Valiente

Abstract

In vivo imaging and therapy represent one of the most promising areas in nanomedicine. Particularly, the identification and localization of nanomaterials within cells and tissues are key issues to understand their interaction with biological components, namely their cell internalization route, intracellular destination, therapeutic activity and possible cytotoxicity. Here, we show the development of multifunctional nanoparticles (NPs) by providing luminescent functionality to zinc and iron oxide NPs. We describe simple synthesis methods based on modified Stöber procedures to incorporate fluorescent molecules on the surface of oxide NPs. These procedures involve the successful coating of NPs with size-controlled amorphous silica (SiO2) shells incorporating standard chromophores like fluorescein, rhodamine B or rhodamine B isothiocyanate. Specifically, spherical Fe3O4 NPs with an average size of 10 nm and commercial ZnO NPs (ca. 130 nm), both coated with an amorphous SiO2 shell of ca. 15 and 24 nm thickness, respectively, are presented. The magnetic nanoparticles, with a major presence of magnetite, show negligible coercitivity. Hence, interactions (dipolar) are very weak and the cores are in the superparamagnetic regime. Spectro...Continue Reading

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Citations

Jun 3, 2020·Pharmaceutics·Nerea Iturrioz-RodríguezMónica L Fanarraga
Feb 16, 2021·ACS Nano·Giovanni M SaladinoMuhammet S Toprak
Dec 20, 2020·International Journal of Molecular Sciences·Ana Rodríguez-RamosMónica L Fanarraga
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bianca Elena-Beatrice CrețuVera Balan

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Methods Mentioned

BETA
fluorescence microscopy
X-ray
transmission electron microscopy
confocal laser microscopy
Confocal microscopy

Software Mentioned

Elements Advanced Research
MAUD
ZFC
TOPAS
NIS

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